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Rabbit Polyclonal AGTRAP Antibody

  • 中文名： AGTRAP抗体
  • 别    名： Type-1 angiotensin II receptor-associated protein, AT1 receptor-associated protein, AGTRAP, ATRAP
货号: IPDX31990
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesType-1 angiotensin II receptor-associated protein, AT1 receptor-associated protein, AGTRAP, ATRAP
Entrez GeneID57085
WB Predicted band size17.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis AGTRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the C-terminal region of human AGTRAP.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于AGTRAP抗体的代表性文献摘要概括(文献为虚构示例，仅作格式参考)：

1. **文献名称**：《AGTRAP modulates angiotensin II receptor signaling in vascular smooth muscle cells》

**作者**：Smith J, et al.

**摘要**：本研究利用特异性AGTRAP抗体证实AGTRAP蛋白通过与AT1受体胞内域结合，负向调控血管紧张素II介导的ERK1/2信号通路，提示其在高血压病理中的潜在调节作用。

2. **文献名称**：《Development of a novel monoclonal antibody for AGTRAP detection in renal tissues》

**作者**：Chen L, et al.

**摘要**：报道一种新型鼠源单克隆抗体的制备及验证，该抗体通过免疫组化成功定位AGTRAP在肾小管上皮细胞的表达，为研究肾脏疾病中血管紧张素系统异常提供工具。

3. **文献名称**：《AGTRAP-antibody complex reveals structural insights into receptor trafficking》

**作者**：Rodriguez M, et al.

**摘要**：通过AGTRAP抗体的共聚焦显微成像及免疫沉淀实验，阐明AGTRAP通过调控AT1受体内吞途径影响细胞膜受体再分布，为受体动态调控机制提供证据。

注：以上文献为模拟内容，实际研究中建议通过PubMed或Web of Science以"AGTRAP antibody"为关键词检索最新文献。

背景信息

The AGTRAP (Angiotensin II Receptor-Associated Protein) antibody is a research tool designed to detect and study the AGTRAP protein, a component of the renin-angiotensin system (RAS). AGTRAP interacts with the angiotensin II type 1 receptor (AT1R), modulating its signaling and internalization. The RAS plays a critical role in blood pressure regulation, fluid balance, and cardiovascular homeostasis, with dysregulation linked to hypertension, heart failure, and kidney disease. AGTRAP's function as a negative regulator of AT1R suggests its involvement in fine-tuning cellular responses to angiotensin II, a key vasoconstrictor peptide. Researchers use AGTRAP antibodies in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to explore its expression patterns, protein-protein interactions, and mechanistic roles in pathophysiological contexts. Studies have implicated AGTRAP in vascular remodeling, metabolic disorders, and potential crosstalk with other signaling pathways, such as MAPK/ERK. Its tissue-specific expression in organs like the heart, kidneys, and blood vessels underscores its relevance to cardiovascular and renal research. The development of AGTRAP antibodies has advanced understanding of RAS complexity, offering insights into therapeutic targets for diseases driven by excessive angiotensin II signaling. However, challenges remain in characterizing its post-translational modifications and context-dependent regulatory effects.

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