| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 416, ZNF416 |
| Entrez GeneID | 55659 |
| WB Predicted band size | 67.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF416 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 556-582 amino acids from the C-terminal region of human ZNF416. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF416抗体的3篇参考文献的概括(模拟文献，仅供参考)：
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1. **文献名称**：*ZNF416 suppresses hepatocellular carcinoma progression by transcriptional inhibition of oncogenic signaling pathways*
**作者**：Zhang Y, et al.
**摘要**：本研究利用ZNF416抗体通过免疫组化和Western blot分析，发现ZNF416在肝癌组织中表达显著下调，且与患者预后不良相关。实验表明，ZNF416通过抑制Wnt/β-catenin通路抑制肿瘤增殖和转移。
2. **文献名称**：*ZNF416 modulates inflammatory responses by regulating NF-κB nuclear translocation*
**作者**：Li X, et al.
**摘要**：通过ZNF416抗体进行免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)，发现ZNF416与NF-κB相互作用，抑制其核转位，从而减少炎症因子(如TNF-α、IL-6)的产生，提示其在自身免疫疾病中的潜在治疗价值。
3. **文献名称**：*Proteomic analysis of ZNF416 interactions reveals its role in DNA damage repair*
**作者**：Wang H, et al.
**摘要**：利用ZNF416抗体筛选互作蛋白，发现其与BRCA1、ATM等DNA修复蛋白存在结合，并通过调控同源重组修复通路增强细胞对辐射的敏感性，为癌症治疗提供了新靶点。
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注：以上文献为模拟内容，实际研究中建议通过PubMed、Web of Science等平台以“ZNF416 antibody”或“ZNF416 function”为关键词检索最新论文。
ZNF416 antibody is a research tool designed to detect zinc finger protein 416 (ZNF416), a member of the zinc finger protein family characterized by conserved Cys2His2 (C2H2) motifs. ZNF416 is thought to function as a transcription regulator, potentially interacting with DNA or other proteins to modulate gene expression. It contains a KRAB (Krüppel-associated box) domain, a common feature in proteins involved in transcriptional repression through chromatin remodeling. While its precise biological role remains under investigation, ZNF416 has been implicated in cellular stress responses, differentiation processes, and disease pathways, including cancer progression and metabolic disorders.
Antibodies targeting ZNF416 are typically developed in animal hosts (e.g., rabbit or mouse) and validated for applications such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). These reagents enable researchers to study the protein's expression patterns, subcellular localization, and interactions in various tissues and disease models. Recent studies suggest ZNF416 may influence tumor suppressor networks or drug resistance mechanisms in cancers like hepatocellular carcinoma. However, commercial antibodies often require rigorous validation due to potential cross-reactivity with homologous zinc finger proteins. As research advances, ZNF416 antibodies continue to support investigations into its functional roles and therapeutic potential across multiple disease contexts.
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