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Rabbit Polyclonal EXD3 Antibody

  • 中文名: EXD3抗体
  • 别    名: Exonuclease mut-7 homolog, 31--, Exonuclease 3'-5' domain-containing protein 3, EXD3
货号: IPDX31991
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesExonuclease mut-7 homolog, 31--, Exonuclease 3'-5' domain-containing protein 3, EXD3
Entrez GeneID54932
WB Predicted band size96.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis EXD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-367 amino acids from the Central region of human EXD3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于EXD3抗体的参考文献示例(注:以下内容为假设性示例,实际文献可能需要通过学术数据库进一步验证):

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1. **文献名称**: "Characterization of a Novel EXD3 Antibody for Detecting DNA Repair Complexes in Human Cells"

**作者**: Johnson M, et al.

**摘要**: 该研究报道了一种针对人源EXD3蛋白的高特异性单克隆抗体的开发,通过免疫印迹和免疫荧光验证其在检测DNA损伤修复复合体中的有效性,并证明EXD3在维持基因组稳定性中的作用。

2. **文献名称**: "EXD3 Deficiency Impairs Meiotic Recombination: Insights from Antibody-Based Localization Studies"

**作者**: Wang Y, et al.

**摘要**: 利用EXD3多克隆抗体进行免疫组化分析,发现EXD3在减数分裂细胞中富集于同源染色体配对区域,其缺失导致重组效率下降,提示其在生殖细胞发育中的关键功能。

3. **文献名称**: "Development of an EXD3-Specific Polyclonal Antibody and Its Application in Cancer Biomarker Screening"

**作者**: Gupta S, et al.

**摘要**: 研究描述了兔源EXD3多克隆抗体的制备过程,并通过质谱和免疫沉淀验证其特异性。该抗体被用于分析多种癌症组织中EXD3的表达水平,发现其与肿瘤侵袭性相关。

4. **文献名称**: "EXD3 Interaction Networks Revealed by Co-Immunoprecipitation Using a Custom Antibody"

**作者**: Lee H, et al.

**摘要**: 通过定制EXD3抗体进行共免疫沉淀实验,鉴定了EXD3与多个DNA修复蛋白(如BRCA2和RAD51)的相互作用,为解析其分子机制提供了新线索。

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**注意**:以上文献为示例,实际引用时请通过PubMed、Google Scholar等平台检索真实存在的文献。若研究主题较为前沿或小众,建议扩展关键词(如“EXD3 AND (antibody OR immunohistochemistry)”)或联系相关领域学者获取资源。

背景信息

The EXD3 antibody targets the EXD3 protein, also known as Exonuclease 3'-5' domain-containing protein 3. a member of the exonuclease family implicated in nucleic acid metabolism. EXD3 is evolutionarily conserved and structurally characterized by its 3'-5' exonuclease domain, suggesting roles in RNA processing, DNA repair, or degradation of aberrant RNA molecules. Though less studied than related exonucleases, emerging research links EXD3 to cellular processes such as spermatogenesis, neuronal development, and mitochondrial RNA homeostasis. Antibodies against EXD3 are primarily used in research to investigate its expression patterns, subcellular localization (e.g., cytoplasmic or mitochondrial), and functional interactions. Studies employing EXD3 antibodies have revealed its potential involvement in maintaining genome stability and regulating translation, with dysregulation observed in contexts like cancer and neurodegenerative diseases. Commercial EXD3 antibodies are typically developed in hosts like rabbits or mice, validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation. However, limited commercial availability and the need for further validation in specific experimental systems remain challenges. Ongoing research aims to clarify EXD3's precise molecular mechanisms and its broader biological significance, particularly in disease pathways.

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