| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | THAP domain-containing protein 10, THAP10 |
| Entrez GeneID | 56906 |
| WB Predicted band size | 28.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This THAP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the N-terminal region of human THAP10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于THAP10 (N-term)抗体的3篇参考文献示例(注：文献为模拟示例，实际研究中需根据具体数据库检索验证)：
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1. **标题**: *THAP10 regulates cell proliferation through transcriptional repression of cyclin-dependent kinase inhibitors*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用THAP10 (N-term)抗体进行免疫沉淀和染色质免疫共沉淀(ChIP)，发现THAP10通过结合CDKN1A和CDKN2B基因启动子区，抑制细胞周期抑制因子的表达，从而促进肿瘤细胞增殖。
2. **标题**: *N-terminal domain of THAP10 mediates its interaction with the NuRD chromatin remodeling complex*
**作者**: Lee S, Kim DH.
**摘要**: 通过Western blot和免疫荧光实验(使用N-term特异性抗体)，作者证实THAP10的N端结构域与NuRD复合体的MTA2亚基直接相互作用，协同调控胚胎干细胞的表观遗传重编程。
3. **标题**: *Tissue-specific expression of THAP10 in murine development revealed by immunohistochemical analysis*
**作者**: Müller R, et al.
**摘要**: 研究采用THAP10 (N-term)抗体进行组织免疫染色，发现THAP10在小鼠胚胎的神经系统和心脏发育中高表达，提示其可能在器官形成中发挥关键作用。
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**备注**：上述文献为示例，实际检索建议通过PubMed、Google Scholar等平台，以关键词“THAP10 antibody N-terminal”或“THAP10 epitope mapping”筛选，并关注抗体应用场景(如WB、IF、IP等)。部分研究可能未明确标注抗体表位，需结合实验方法描述或联系原文作者确认。
The THAP10 (N-term) antibody is designed to target the N-terminal region of the THAP10 protein, a member of the THAP (Thanatos-associated protein) family. THAP proteins are characterized by a conserved zinc-dependent DNA-binding domain (THAP domain) and play roles in transcriptional regulation, chromatin modification, and cell cycle control. THAP10. though less studied compared to other THAP members, is implicated in transcriptional repression and chromatin organization, potentially influencing cell differentiation and apoptosis. The N-terminal region of THAP10 may contain functional motifs critical for protein-protein interactions or regulatory activity, making this antibody a tool for investigating its molecular mechanisms.
This antibody is commonly used in techniques like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP) to study THAP10 expression, localization, and interactions in cellular models. Researchers employ it to explore THAP10's role in gene regulation, its involvement in diseases like cancer, or its crosstalk with epigenetic modifiers. Validation typically includes testing in knockdown/overexpression systems to confirm specificity. Host species (e.g., rabbit or mouse) and clonality (polyclonal/monoclonal) vary by commercial source, with optimization required for experimental conditions. Its development aids in elucidating THAP10's biological significance within the THAP protein network.
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