| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein tweety homolog 1, hTTY1, TTYH1 |
| Entrez GeneID | 57348 |
| WB Predicted band size | 49.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TTYH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-28 amino acids from the N-terminal region of human TTYH1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是模拟生成的关于 TTYH1 (N-term) 抗体的参考文献示例(仅供参考，非真实文献)：
---
1. **Title**: *TTYH1 expression in glioblastoma: Role of N-terminal antibody in tumor progression analysis*
**Author**: Li, X. et al.
**Summary**: 该研究利用TTYH1 N端特异性抗体，通过免疫组化及Western blot技术，揭示了TTYH1在胶质母细胞瘤中的高表达，并发现其表达水平与肿瘤侵袭性和患者预后不良相关。抗体验证显示其特异性靶向细胞膜定位的TTYH1蛋白。
2. **Title**: *Development of a monoclonal antibody against TTYH1 N-terminus and its application in breast cancer models*
**Author**: Sanchez, R. et al.
**Summary**: 本研究报道了一种针对TTYH1蛋白N端表位的单克隆抗体的开发与验证。通过流式细胞术和免疫荧光实验，证实该抗体可特异性识别乳腺癌细胞系中的TTYH1.并用于探究其在细胞迁移和转移中的功能机制。
3. **Title**: *TTYH1 ion channel function explored via N-terminal antibody blockade in neuronal cells*
**Author**: Kumar, V. & Jung, H.
**Summary**: 利用TTYH1 N端抗体阻断实验，研究团队发现TTYH1在神经元细胞中作为氯离子通道的关键作用。抗体干扰实验表明，TTYH1活性缺失会导致细胞体积调节异常，提示其在中枢神经系统疾病中的潜在病理意义。
4. **Title**: *Proteomic analysis of TTYH1 interactions using N-terminal epitope tagging*
**Author**: Gao, Y. et al.
**Summary**: 通过构建TTYH1 N端表位标签系统并结合免疫共沉淀(Co-IP)技术，该研究鉴定了TTYH1与细胞骨架蛋白的相互作用网络，为解析其参与细胞形态调控的分子机制提供了新证据。
---
**注**：以上文献为示例性内容，实际引用时需检索真实数据库(如PubMed、Web of Science)获取准确信息。
The TTYH1 (N-term) antibody is a research tool designed to target the N-terminal region of the Tweety homolog 1 (TTYH1) protein, a member of the conserved Tweety family. TTYH1 is implicated in ion channel regulation, cell adhesion, and volume regulation, though its precise molecular mechanisms remain under investigation. It is broadly expressed in tissues, including the brain, and has gained attention for its potential role in cancer biology, particularly in glioblastoma, breast cancer, and other malignancies where it may influence cell proliferation, migration, and apoptosis.
The N-terminal domain of TTYH1 is critical for its function, possibly mediating protein-protein interactions or modulating ion transport activity. The TTYH1 (N-term) antibody enables researchers to study the protein's expression, localization, and post-translational modifications via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region helps distinguish TTYH1 from other Tweety family members (TTYH2. TTYH3), aiding in isoform-specific studies.
Recent studies highlight TTYH1's dual role as a chloride channel regulator and a biomarker for certain cancers, linking its overexpression to tumor progression and poor prognosis. This antibody thus serves as a vital tool for unraveling TTYH1's physiological and pathological roles, offering insights into therapeutic targeting opportunities. Validation in specific experimental models ensures reliability, though researchers are advised to confirm cross-reactivity and optimal conditions for their applications.
×
