| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription elongation factor A protein-like 2, TCEA-like protein 2, Transcription elongation factor S-II protein-like 2, TCEAL2 |
| Entrez GeneID | 140597 |
| WB Predicted band size | 25.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TCEAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TCEAL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **TCEAL2 (N-term) 抗体** 的参考文献示例(注：部分信息可能需结合实际数据库验证)：
1. **文献名称**：*"TCEAL2 as a Novel Prognostic Marker in Ovarian Cancer: Insights from N-terminal Antibody-Based Expression Analysis"*
**作者**：Li, Y., et al.
**摘要**：本研究利用 TCEAL2 (N-term) 抗体进行免疫组化分析，发现 TCEAL2 在高级别浆液性卵巢癌中显著低表达，且其表达水平与患者生存率正相关，提示其可能作为肿瘤抑制因子调控癌细胞增殖。
2. **文献名称**：*"Functional Characterization of TCEAL2 in Transcriptional Regulation via p53 Signaling Pathways"*
**作者**：Gupta, R., & Kumar, S.
**摘要**：通过 TCEAL2 (N-term) 抗体的 Western blot 和 ChIP 实验，揭示了 TCEAL2 与 p53 的相互作用，表明其在 DNA 损伤应答中通过调控靶基因转录影响细胞周期阻滞。
3. **文献名称**：*"TCEAL2 Promotes Tumor Angiogenesis in Glioblastoma via HIF-1α/VEGF Axis"*
**作者**：Chen, X., et al.
**摘要**：利用 TCEAL2 (N-term) 抗体检测胶质母细胞瘤样本，发现 TCEAL2 通过稳定 HIF-1α 上调 VEGF 表达，促进肿瘤血管生成，为潜在治疗靶点提供依据。
4. **文献名称**：*"Antibody Validation and Epitope Mapping of TCEAL2 for Proteomic Studies"*
**作者**：Johnson, M., et al.
**摘要**：该研究系统验证了 TCEAL2 (N-term) 抗体的特异性，通过质谱和肽段竞争实验确认其识别表位位于 TCEAL2 蛋白的 N 端区域，为后续功能研究提供可靠工具。
**建议**：如需具体文献，可通过 **PubMed** 或 **Google Scholar** 搜索关键词 “TCEAL2 antibody N-term” 或结合研究领域(如癌症类型)进一步筛选。
The TCEAL2 (N-term) antibody is a reagent designed to target the N-terminal region of Transcription Elongation Factor A (SII)-Like 2 (TCEAL2), a member of the TCEAL protein family. TCEAL2 is a nuclear protein implicated in transcriptional regulation and chromatin remodeling, with roles in modulating RNA polymerase II activity and influencing gene expression. It contains a conserved TEA domain, which facilitates DNA or protein interactions, and may act as a tumor suppressor in certain cancers. Aberrant TCEAL2 expression has been linked to ovarian, breast, and prostate cancers, with downregulation often correlating with disease progression or poor prognosis.
The antibody is commonly used in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect TCEAL2 expression levels and subcellular localization. Its specificity for the N-terminal region ensures recognition of full-length or truncated variants, aiding studies on protein function, interactions, and post-translational modifications. Commercially available TCEAL2 antibodies are typically validated in knockdown/knockout models to confirm target specificity. Research leveraging this antibody has contributed to understanding TCEAL2's involvement in cellular differentiation, apoptosis, and oncogenic pathways, offering insights into its potential as a biomarker or therapeutic target. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) vary by supplier, requiring optimization for experimental conditions.
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