| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RING finger protein 26, RNF26 |
| Entrez GeneID | 79102 |
| WB Predicted band size | 47.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RNF26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-273 amino acids from the Central region of human RNF26. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RNF26抗体的3篇参考文献示例(信息基于模拟生成，具体文献需核实)：
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1. **文献名称**: *RNF26 regulates the selective autophagy of endoplasmic reticulum during stress recovery*
**作者**: Smith A, et al.
**摘要**: 研究揭示了RNF26通过调控泛素化修饰，介导内质网相关蛋白的自噬降解。研究中使用RNF26抗体进行免疫共沉淀，证实其与自噬受体蛋白的相互作用，并发现RNF26在细胞应激恢复中的关键作用。
2. **文献名称**: *RNF26 modulates innate immune signaling by organizing antiviral protein complexes*
**作者**: Chen L, et al.
**摘要**: 本文发现RNF26通过形成细胞质信号平台调控抗病毒先天免疫应答。通过RNF26抗体的Western blot和免疫荧光实验，证实其在病毒感染后招募STING和MAVS蛋白，促进I型干扰素产生。
3. **文献名称**: *The E3 ligase RNF26 stabilizes specific ER-mitochondrial contact sites and regulates calcium signaling*
**作者**: Gómez-Sánchez R, et al.
**摘要**: 研究利用RNF26抗体进行亚细胞定位分析，发现RNF26通过泛素化稳定内质网-线粒体接触位点，调控钙离子稳态。敲除RNF26导致细胞钙信号异常和线粒体功能障碍。
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如需具体文献，建议通过PubMed或Google Scholar检索DOI获取全文。
The RNF26 antibody is a research tool designed to target the RING finger protein 26 (RNF26), a member of the E3 ubiquitin ligase family involved in ubiquitination processes. RNF26 is characterized by its N-terminal transmembrane domain and a C-terminal RING finger motif, enabling it to regulate protein degradation, trafficking, and immune signaling. It localizes to the endoplasmic reticulum (ER) and plays roles in coordinating ER-associated degradation (ERAD), autophagy, and the innate immune response by modulating STING-dependent signaling pathways.
Antibodies against RNF26 are primarily used in studies exploring intracellular protein dynamics, particularly in contexts like cancer, neurodegenerative diseases, and viral infections. Researchers employ these antibodies in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to detect RNF26 expression, assess its interaction with substrates (e.g., VCP/p97 or STING), and study its role in stress response pathways.
The development and validation of RNF26 antibodies have been driven by the need to understand its dual roles in protein quality control and immune regulation. Dysregulation of RNF26 has been linked to disrupted autophagy, ER stress, and altered cytokine production, making it a potential therapeutic target. Commercial antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown. Ongoing research focuses on clarifying its mechanistic contributions to diseases and its interplay with other ubiquitin ligases in cellular homeostasis.
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