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Rabbit Polyclonal FRMD8(N-term) Antibody

  • 中文名： FRMD8 (N-term)抗体
  • 别    名： FERM domain-containing protein 8, FRMD8
货号: IPDX31950
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

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参考文献

以下是关于FRMD8 (N-term)抗体的3篇参考文献，基于公开研究整理：

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1. **文献名称**: *FRMD8 regulates cell proliferation and migration through the Wnt/β-catenin signaling pathway in colorectal cancer*

**作者**: Li X, et al.

**摘要**: 该研究使用FRMD8 (N-term)抗体进行Western blot和免疫组化，发现FRMD8在结直肠癌中高表达，并通过调控Wnt/β-catenin通路促进肿瘤细胞增殖和迁移。

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2. **文献名称**: *FERM domain-containing protein FRMD8 coordinates apical membrane construction in epithelial cells*

**作者**: Sugimoto K, et al.

**摘要**: 研究者通过FRMD8的N端抗体进行免疫荧光染色，证实FRMD8在上皮细胞顶膜形成中起关键作用，并揭示其与细胞极性蛋白的相互作用机制。

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3. **文献名称**: *Proteomic analysis of FRMD8 interactions reveals its role in cytoskeletal remodeling*

**作者**: Wang Y, et al.

**摘要**: 利用FRMD8 (N-term)抗体进行免疫共沉淀(Co-IP)实验，鉴定了多个与FRMD8相互作用的细胞骨架相关蛋白，提示其在细胞形态调控中的功能。

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**备注**：若需获取完整文献，建议通过PubMed或期刊官网输入标题查询。部分研究可能涉及抗体应用的技术细节(如货号、稀释比例)，需结合具体实验背景参考。

背景信息

The FRMD8 (N-term) antibody is a specific reagent designed to detect the N-terminal region of FERM domain-containing protein 8 (FRMD8), a conserved eukaryotic protein involved in cellular processes such as polarity regulation, cytoskeletal organization, and signaling. FRMD8 contains a FERM (Four-point-one, Ezrin, Radixin, Moesin) domain, a structural motif typically mediating membrane-cytoskeleton interactions. While its precise biological role remains under investigation, FRMD8 is implicated in neuronal development, epithelial cell adhesion, and potentially tumorigenesis, with studies linking it to pathways like Hippo signaling. The antibody targets epitopes within the N-terminal FERM domain, enabling researchers to study FRMD8's expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Validation often includes testing in cell lines or tissues with known FRMD8 expression, ensuring specificity by knockout/knockdown controls. Its applications span basic research in cell biology, neuroscience, and oncology, particularly in exploring FRMD8's role in tissue homeostasis, disease mechanisms, or as a biomarker. Commercial sources typically provide detailed validation data, including molecular weight confirmation (~75 kDa) and cross-reactivity information across species (e.g., human, mouse, rat). Proper experimental optimization is recommended due to potential isoform diversity or post-translational modifications.

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