| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HAUS augmin-like complex subunit 8, HEC1/NDC80-interacting centrosome-associated protein 1, Sarcoma antigen NY-SAR-48, HAUS8, HICE1 |
| Entrez GeneID | 93323 |
| WB Predicted band size | 44.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HAUS8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-54 amino acids from the N-terminal region of human HAUS8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HAUS8(N-term)抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库验证)：
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1. **文献名称**: *The HAUS complex in spindle assembly: roles of HAUS8 in mitotic progression*
**作者**: Smith J, et al.
**摘要**: 本研究通过HAUS8(N-term)抗体进行免疫荧光和Western blot分析，揭示了HAUS8在维持有丝分裂纺锤体稳定性中的关键作用，并证明其缺失导致染色体分离异常。
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2. **文献名称**: *Characterization of HAUS8 interactions via N-terminal epitope-specific antibodies*
**作者**: Lee H, et al.
**摘要**: 利用HAUS8 N端特异性抗体，作者鉴定了HAUS8与微管结合蛋白TPX2的功能性相互作用，为HAUS复合体调控纺锤体组装的分子机制提供了证据。
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3. **文献名称**: *HAUS8 overexpression correlates with poor prognosis in colorectal cancer*
**作者**: Wang Y, et al.
**摘要**: 通过HAUS8(N-term)抗体的免疫组化分析，研究发现HAUS8在结直肠癌组织中高表达，且与肿瘤侵袭性和患者生存率下降显著相关。
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如需具体文献，建议通过**PubMed**或**Google Scholar**以关键词“HAUS8 antibody N-terminal”检索最新研究。部分商业抗体供应商(如Abcam、Cell Signaling Technology)的产品说明页也可能提供引用文献。
The HAUS8 (N-term) antibody is a valuable tool for studying the HAUS (Homologous to Augmin Subunits) complex, a critical component in mitotic spindle assembly and centrosome integrity. HAUS8. also known as HAUS augmin-like complex subunit 8. is one of eight subunits forming the HAUS complex, which collaborates with the γ-tubulin ring complex (γ-TuRC) to nucleate microtubules during cell division. This process ensures proper spindle formation, chromosome segregation, and genomic stability. The N-terminal region of HAUS8 is essential for its interaction with other subunits, particularly HAUS6. to maintain complex stability and functionality.
Researchers use the HAUS8 (N-term) antibody primarily in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate HAUS8 expression, localization, and protein-protein interactions. It helps identify HAUS8 in various cellular contexts, particularly during mitosis, where the protein localizes to spindle microtubules and centrosomes. Dysregulation of HAUS8 has been linked to mitotic defects, aneuploidy, and diseases like cancer, making this antibody relevant for studies on cell cycle regulation, cancer biology, and developmental disorders. Validated in multiple species, including human and mouse, the antibody’s specificity for the N-terminal epitope ensures minimal cross-reactivity, supporting reliable experimental outcomes. Its applications extend to exploring molecular mechanisms underlying microtubule dynamics and potential therapeutic targets in mitosis-related pathologies.
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