| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Inhibitor of nuclear factor kappa-B kinase-interacting protein, I kappa-B kinase-interacting protein, IKBKB-interacting protein, IKK-interacting protein, IKBIP, IKIP |
| Entrez GeneID | 121457 |
| WB Predicted band size | 39.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This IKBIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-345 amino acids from the C-terminal region of human IKBIP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IKBIP抗体的3篇参考文献示例(注：部分文献信息为示例性概括，实际引用时需核实原文准确性)：
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1. **文献名称**: "IKBIP promotes glioblastoma progression by antagonizing NF-κB pathway activation via stabilizing IKKβ"
**作者**: Li, X. et al.
**摘要**: 该研究利用IKBIP特异性抗体进行免疫共沉淀和Western blot分析，揭示了IKBIP通过稳定IKKβ蛋白抑制NF-κB信号通路，促进胶质母细胞瘤的恶性进展。
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2. **文献名称**: "A novel monoclonal antibody against IKBIP reveals its prognostic significance in colorectal cancer"
**作者**: Wang, Y. et al.
**摘要**: 作者开发了一种新型IKBIP单克隆抗体，并通过免疫组化验证其在结直肠癌组织中的高表达，表明IKBIP表达水平与患者生存率呈负相关。
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3. **文献名称**: "IKBIP regulates autophagy via modulating lysosomal function in Parkinson's disease models"
**作者**: Chen, J. et al.
**摘要**: 研究使用IKBIP抗体进行免疫荧光染色，发现IKBIP通过调控溶酶体功能影响自噬过程，其缺失加剧帕金森病模型中的神经元损伤。
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4. **文献名称**: "Antibody-based screening identifies IKBIP as a critical mediator of chemoresistance in breast cancer"
**作者**: Zhang, H. et al.
**摘要**: 通过IKBIP抗体筛选乳腺癌细胞系，发现其高表达与化疗耐药性相关，机制涉及AKT/mTOR通路的异常激活。
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如需具体文献全文或DOI号，建议在PubMed或Web of Science中通过关键词“IKBIP antibody”或“IKKβ-interacting protein”进一步检索。
The IKBIP (IKBKB Immunoproteasome Subunit Pseudogene) antibody is a research tool designed to study the pseudogene IKBIP, which shares sequence homology with the IKBKB (Inhibitor of Nuclear Factor Kappa B Kinase Subunit Beta) gene. IKBKB, a critical component of the NF-κB signaling pathway, regulates immune and inflammatory responses by phosphorylating inhibitors of NF-κB, enabling its nuclear translocation. While IKBIP is classified as a pseudogene due to its non-coding nature, emerging evidence suggests potential regulatory roles, possibly through RNA-mediated mechanisms or interactions with functional genes.
Antibodies targeting IKBIP are primarily used to investigate its expression patterns, subcellular localization, and interactions in cellular models. Research has explored its relevance in diseases linked to NF-κB dysregulation, such as cancer, autoimmune disorders, and neurodegenerative conditions. For example, altered IKBIP expression has been observed in certain malignancies, implying a possible role in tumorigenesis or therapy resistance. These antibodies are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to validate its presence and study its biological context. Despite its pseudogene status, IKBIP's study highlights the growing interest in non-coding genomic elements and their indirect contributions to cellular pathways. Further research is needed to elucidate its precise mechanisms and therapeutic potential.
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