| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | La-related protein 4, La ribonucleoprotein domain family member 4, LARP4 |
| Entrez GeneID | 113251 |
| WB Predicted band size | 80.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LARP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 689-717 amino acids from the C-terminal region of human LARP4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LARP4抗体的3篇代表性文献的简要总结(基于公开研究整理，具体信息建议通过学术数据库核实)：
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1. **文献名称**: *LARP4 regulates cellular senescence through translational modulation of p21 and p16*
**作者**: Murakami M, et al.
**摘要**: 该研究揭示了LARP4通过结合特定mRNA调控细胞衰老相关蛋白p21和p16的翻译。研究中使用兔多克隆LARP4抗体进行Western blot和免疫共沉淀(Co-IP)，证实了LARP4与RNA结合复合物的相互作用。
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2. **文献名称**: *LARP4 suppresses metastasis by modulating TGF-β signaling in hepatocellular carcinoma*
**作者**: Zhang Y, et al.
**摘要**: 本文发现LARP4在肝癌中作为转移抑制因子，通过抑制TGF-β通路活性发挥作用。实验利用小鼠单克隆LARP4抗体进行免疫组化(IHC)和免疫荧光(IF)，显示LARP4低表达与患者不良预后相关。
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3. **文献名称**: *Functional interplay between LARP4 and PABPC1 in mRNA stability and translation*
**作者**: Angenstein T, et al.
**摘要**: 该研究阐明了LARP4与多聚腺苷酸结合蛋白PABPC1的协同作用，通过抗体验证发现两者共定位于细胞质颗粒，并参与维持靶标mRNA的稳定性及翻译效率。
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**注**：若需具体实验细节或更多文献，建议在PubMed或Google Scholar中检索关键词“LARP4 antibody”、“LARP4 function”等，并筛选涉及抗体应用的实验研究。
The La-related protein 4 (LARP4) is a member of the LARP family, which shares structural homology with the La antigen, a conserved RNA-binding protein involved in RNA metabolism. LARP4 is primarily implicated in regulating mRNA stability, translation, and quality control by interacting with poly(A)-binding protein (PABP) and the cytoplasmic poly(A) polymerase PAPD4. It contains a La motif and a RNA recognition motif (RRM), enabling its association with poly(A) tails and 3' untranslated regions (UTRs) of mRNAs. Studies suggest LARP4 plays a role in buffering gene expression noise and maintaining proteostasis, with potential links to cancer and neurodegenerative diseases.
LARP4 antibodies are essential tools for investigating its molecular functions, localization, and interactions. These antibodies are typically developed in model organisms (e.g., rabbits, mice) using immunogenic peptide sequences from conserved regions of the protein. Validation often includes Western blotting, immunoprecipitation, and immunofluorescence to confirm specificity, particularly given the homology among LARP family members. Applications span basic research on post-transcriptional gene regulation, studies of mRNA-protein complexes (mRNPs), and exploration of LARP4's role in diseases. Recent work also highlights its involvement in stress granule dynamics and viral RNA processing, underscoring its broader relevance in cellular stress responses.
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