| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phosphoglucomutase-like protein 5, Aciculin, Phosphoglucomutase-related protein, PGM-RP, PGM5, PGMRP |
| Entrez GeneID | 5239 |
| WB Predicted band size | 62.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PGM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-430 amino acids from the C-terminal region of human PGM5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于PGM5抗体的3篇代表性文献的简要信息，供参考：
---
1. **标题**：*PGM5 suppresses colorectal cancer metastasis by inhibiting TGF-β signaling*
**作者**：Zhang Y, et al.
**摘要**：研究揭示PGM5在结直肠癌中通过调控TGF-β信号通路抑制肿瘤转移，实验中利用PGM5抗体进行Western blot和免疫组化，证实PGM5低表达与患者预后不良相关。
---
2. **标题**：*Phosphoglucomutase 5 deficiency exacerbates pulmonary fibrosis via Akt signaling*
**作者**：Li X, et al.
**摘要**：探讨PGM5在肺纤维化中的作用，研究使用PGM5抗体检测肺组织中的蛋白表达，发现PGM5缺失通过激活Akt通路促进纤维化进展。
---
3. **标题**：*PGM5 as a novel biomarker for gastric cancer diagnosis*
**作者**：Wang H, et al.
**摘要**：该研究提出PGM5作为胃癌潜在诊断标志物，通过PGM5抗体进行ELISA和免疫荧光分析，发现胃癌患者血清PGM5水平显著降低。
---
**说明**：以上文献为模拟示例，实际引用需通过PubMed、Web of Science等平台检索具体论文(关键词：PGM5 antibody, phosphoglucomutase 5. cancer/fibrosis)。部分研究可能由抗体公司(如CST、Abcam)提供技术文档支持。
Phosphoglucomutase 5 (PGM5) is an enzyme belonging to the phosphoglucomutase family, which plays a critical role in carbohydrate metabolism by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. This reversible reaction is essential for glycogen breakdown and synthesis, as well as glycolysis. PGM5. specifically, is one of several isoforms (PGM1–PGM5) encoded by distinct genes, with tissue-specific expression patterns. Unlike the widely expressed PGM1. PGM5 is predominantly found in smooth muscle and other tissues, where it is implicated in cytoskeletal organization and cell adhesion through interactions with actin filaments.
Antibodies targeting PGM5 are valuable tools in biomedical research, particularly for studying its expression, localization, and functional roles in physiological and pathological contexts. Dysregulation of PGM5 has been linked to diseases such as cancer, fibrosis, and vascular disorders. For instance, reduced PGM5 expression is observed in certain tumors, correlating with epithelial-mesenchymal transition (EMT) and metastasis. In fibrosis, PGM5 deficiency may contribute to abnormal extracellular matrix remodeling.
PGM5 antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels or visualize tissue distribution. Their specificity and reliability are critical for elucidating PGM5's molecular mechanisms and potential therapeutic applications. However, cross-reactivity with other PGM isoforms remains a challenge, necessitating rigorous validation. Ongoing research aims to clarify PGM5's dual metabolic and structural roles, highlighting its significance in cellular homeostasis and disease pathways.
×
