| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tropomodulin-4, Skeletal muscle tropomodulin, Sk-Tmod, TMOD4 |
| Entrez GeneID | 29765 |
| WB Predicted band size | 39.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TMOD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-176 amino acids from the Central region of human TMOD4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是假设性的TMOD4抗体相关文献示例(请注意，以下内容为模拟创作，实际文献需通过学术数据库查询)：
1. **《Tropomodulin 4 regulates actin cytoskeleton organization in epithelial cells》**
- **作者**: Smith A, et al. (2020)
- **摘要**: 研究通过TMOD4特异性抗体，揭示了TMOD4在调控上皮细胞肌动蛋白动态平衡中的作用，发现其缺失导致细胞迁移能力下降。
2. **《TMOD4 overexpression in breast cancer and its diagnostic implications》**
- **作者**: Chen L, et al. (2019)
- **摘要**: 利用TMOD4抗体进行免疫组化分析，发现乳腺癌组织中TMOD4高表达与患者预后不良相关，提示其作为潜在生物标志物的价值。
3. **《Role of TMOD4 in cardiomyocyte development: Insights from antibody-based knockout models》**
- **作者**: Tanaka K, et al. (2018)
- **摘要**: 通过TMOD4抗体验证基因敲除模型，证明TMOD4在心肌细胞肌节组装中的关键作用，缺陷导致心脏收缩功能异常。
4. **《Antibody validation for TMOD4 in erythrocyte membrane studies》**
- **作者**: Gupta R, et al. (2021)
- **摘要**: 研究系统验证了TMOD4抗体的特异性，并应用于红细胞膜蛋白分析，证实TMOD4对细胞膜稳定性的调控机制。
建议通过 **PubMed** 或 **Web of Science** 检索关键词 "TMOD4 antibody" 或 "Tropomodulin 4" 获取真实文献。
The TMOD4 antibody is a research tool designed to detect tropomodulin-4 (TMOD4), a member of the tropomodulin family of actin-binding proteins. TMOD4 plays a critical role in regulating actin filament dynamics by stabilizing the pointed (slow-growing) ends of actin filaments, particularly in non-muscle cells and certain specialized tissues. Unlike its isoforms (TMOD1-3), which are predominantly expressed in muscle or erythroid cells, TMOD4 is broadly distributed in tissues such as the brain, kidney, and immune cells, suggesting diverse roles in cytoskeletal organization, cell motility, and membrane stability.
Studies involving TMOD4 antibodies have focused on unraveling its function in cellular processes like neuronal development, immune cell migration, and cancer metastasis. For instance, TMOD4 has been implicated in modulating dendritic spine morphology in neurons and influencing the invasive behavior of cancer cells. The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to localize TMOD4 expression and assess its interaction with other cytoskeletal components.
Commercial TMOD4 antibodies are typically validated for specificity and cross-reactivity across species (e.g., human, mouse, rat). Researchers employ these antibodies to explore TMOD4's involvement in diseases linked to cytoskeletal dysregulation, such as neurodegenerative disorders or metastatic cancers. Ongoing work aims to clarify its regulatory mechanisms and potential as a therapeutic target, making TMOD4 antibodies essential for both basic and translational studies.
×
