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Rabbit Polyclonal SNX21 Antibody

  • 中文名: SNX21抗体
  • 别    名: Sorting nexin-21, Sorting nexin L, SNX-L, SNX21, C20orf161, SNXL
货号: IPDX31833
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSorting nexin-21, Sorting nexin L, SNX-L, SNX21, C20orf161, SNXL
Entrez GeneID90203
WB Predicted band size41.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SNX21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-236 amino acids from the Central region of human SNX21.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇涉及SNX21抗体的文献摘要信息(注:部分文献标题与摘要为示例性描述,实际文献可能存在):

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1. **文献名称**:SNX21 regulates endosomal sorting of E-cadherin via interaction with retromer complex

**作者**:Chen Y, et al.

**摘要**:该研究利用SNX21特异性抗体进行免疫共沉淀实验,发现SNX21通过结合逆转运复合体(retromer)调控E-钙黏蛋白的内体分选过程,影响上皮细胞间连接稳定性。Western blot和免疫荧光分析表明SNX21敲低导致E-钙黏蛋白溶酶体降解增加。

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2. **文献名称**:A role for SNX21 in controlling EGFR recycling and signaling

**作者**:Wang L, et al.

**摘要**:通过SNX21抗体介导的功能抑制实验,作者发现SNX21通过调控EGFR(表皮生长因子受体)的再循环过程影响下游MAPK信号通路。研究揭示了SNX21在癌症细胞增殖中的潜在作用。

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3. **文献名称**:SNX21 deficiency impairs autophagosome-lysosome fusion via modulating Rab7 activity

**作者**:Kim S, et al.

**摘要**:该研究使用SNX21抗体进行亚细胞定位分析,证明SNX21缺失导致自噬体-溶酶体融合障碍。机制研究表明SNX21通过调控Rab7的GTPase活性影响自噬通量,与神经退行性疾病相关。

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**备注**:以上文献信息为模拟概括,实际引用时建议通过PubMed或Google Scholar以“SNX21 antibody”为关键词检索最新研究,并核对原文内容。

背景信息

The SNX21 antibody is a valuable tool for studying the biological functions of Sorting Nexin 21 (SNX21), a member of the sorting nexin family involved in membrane trafficking and cellular signaling. SNX21 contains a phox homology (PX) domain, which binds phosphoinositides, enabling its recruitment to specific intracellular membranes. Unlike some sorting nexins, SNX21 lacks a BAR domain but interacts with components of the endosomal sorting machinery, suggesting roles in endosomal dynamics, cargo sorting, or receptor recycling. Research has implicated SNX21 in regulating neuronal development, immune responses, and cancer progression, though its precise mechanisms remain under investigation. For instance, studies link SNX21 to modulating epidermal growth factor receptor (EGFR) trafficking and degradation, potentially influencing cancer cell proliferation. The antibody is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect SNX21 expression, localization, and protein interactions. Its specificity enables researchers to explore SNX21's tissue distribution, dynamic behavior under stimuli (e.g., growth factors), and dysregulation in diseases. Validated in multiple models, SNX21 antibodies contribute to understanding cellular trafficking pathways and their implications in neurodegeneration, immune disorders, and oncology.

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