| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gliomedin, GLDN, COLM |
| Entrez GeneID | 342035 |
| WB Predicted band size | 59.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GLDN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-299 amino acids from the Central region of human GLDN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GLDN(Gliomedin)抗体的3篇参考文献示例(内容基于公开研究主题整理，非真实文献)：
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1. **文献名称**：*Gliomedin mediates Schwann cell-axon interaction and node of Ranvier assembly*
**作者**：Feinberg K, et al.
**摘要**：研究揭示了Gliomedin(GLDN)在施万细胞表面的表达及其在周围神经节点形成中的关键作用。通过抗体阻断实验，证明GLDN通过与神经轴突的相互作用促进细胞黏附及髓鞘分子聚集。
2. **文献名称**：*Autoantibodies targeting gliomedin in Guillain-Barré syndrome*
**作者**：Lopez PH, et al.
**摘要**：探讨了自身免疫性神经疾病(如格林-巴利综合征)患者血清中抗GLDN抗体的存在，提示其可能通过干扰神经节点结构导致传导功能障碍。
3. **文献名称**：*Structural and functional analysis of gliomedin in peripheral nerve development*
**作者**：Eshed-Eisenbach Y, et al.
**摘要**：利用特异性GLDN抗体进行免疫定位，阐明了该蛋白在发育过程中对轴突引导及施万细胞分化的调控机制。
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**注**：以上文献为示例，实际研究请通过PubMed、Google Scholar等平台检索最新论文。
**Background of GLDN Antibody**
The glial cell line-derived neurotrophic factor (GDNF) family ligand neurturin (NRTN) receptor, commonly referred to as GLDN (Gliomedin), is a transmembrane protein predominantly expressed in peripheral nerves, specifically by Schwann cells. It plays a critical role in the formation and maintenance of the nodes of Ranvier, specialized regions essential for saltatory conduction of nerve impulses. GLDN interacts with axonal cell adhesion molecules, such as neurofascin-186 (NF186) and contactin-1. to cluster voltage-gated sodium channels (Nav) at nodal sites, ensuring efficient nerve signaling.
Antibodies targeting GLDN are valuable tools in neuroscience research, particularly for studying myelination, nodal organization, and peripheral nerve regeneration. They enable visualization of GLDN expression in Schwann cells and its localization at paranodal junctions via techniques like immunohistochemistry and immunofluorescence. Dysregulation of GLDN has been implicated in demyelinating disorders, such as Charcot-Marie-Tooth disease, making these antibodies relevant for investigating pathological mechanisms or therapeutic strategies.
Additionally, GLDN antibodies aid in distinguishing between nodal and paranodal structures in experimental models, contributing to our understanding of nerve development and repair. Their specificity and utility in both in vitro and in vivo studies underscore their importance in advancing neurobiology and translational research related to peripheral neuropathies.
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