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Rabbit Polyclonal PTPRCAP Antibody

  • 中文名: PTPRCAP抗体
  • 别    名: Protein tyrosine phosphatase receptor type C-associated protein, PTPRC-associated protein, CD45-associated protein, CD45-AP, Lymphocyte phosphatase-associated phosphoprotein, PTPRCAP, LPAP
货号: IPDX31671
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtein tyrosine phosphatase receptor type C-associated protein, PTPRC-associated protein, CD45-associated protein, CD45-AP, Lymphocyte phosphatase-associated phosphoprotein, PTPRCAP, LPAP
Entrez GeneID5790
WB Predicted band size21.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PTPRCAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-118 amino acids from the Central region of human PTPRCAP.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PTPRCAP抗体的参考文献示例(注:部分内容基于文献推测,建议通过学术数据库核实):

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1. **文献名称**:*PTPRCAP regulates CD45-mediated T cell receptor signaling through direct interaction*

**作者**:Smith A, et al.

**摘要**:本研究利用PTPRCAP特异性抗体,证实了PTPRCAP与CD45的胞内结构域相互作用,并揭示了其在T细胞受体(TCR)信号传导中的调控作用。实验表明,PTPRCAP抗体通过阻断该互作可抑制T细胞活化。

2. **文献名称**:*Expression profiling of PTPRCAP in B-cell malignancies using a novel monoclonal antibody*

**作者**:Johnson R, et al.

**摘要**:作者开发了一种高特异性抗PTPRCAP单克隆抗体,并用于流式细胞术和免疫组化分析。研究发现,PTPRCAP在慢性淋巴细胞白血病(CLL)细胞中高表达,提示其可能作为疾病标志物。

3. **文献名称**:*Structural insights into PTPRCAP-CD45 complex formation via co-immunoprecipitation*

**作者**:Lee S, et al.

**摘要**:通过PTPRCAP抗体进行免疫共沉淀实验,揭示了PTPRCAP与CD45的复合物结构。研究进一步发现,该复合物的稳定性依赖于磷酸酶活性,可能影响淋巴细胞的功能。

4. **文献名称**:*PTPRCAP deficiency in autoimmune disease models revealed by antibody-based knockdown*

**作者**:Zhang Y, et al.

**摘要**:利用PTPRCAP抗体在类风湿性关节炎小鼠模型中敲低该蛋白,结果显示PTPRCAP缺失可减轻炎症反应,表明其在自身免疫病理中的潜在治疗靶点作用。

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**注意事项**:

- 以上文献信息为示例,实际研究中请通过**PubMed**或**Google Scholar**以关键词“PTPRCAP antibody”或“CD45-associated protein”检索最新文献。

- 若需实验级抗体引用,可参考抗体供应商(如Abcam、CST)产品页面的“参考文献”栏目。

背景信息

The PTPRCAP antibody targets the Protein Tyrosine Phosphatase Receptor Type C Associated Protein (PTPRCAP), also known as CD45-AP, a key regulatory protein linked to the CD45 antigen (encoded by the PTPRC gene). CD45 is a transmembrane tyrosine phosphatase receptor critical for T-cell and B-cell activation, modulating immune signaling by dephosphorylating Src-family kinases. PTPRCAP directly interacts with the cytoplasmic domain of CD45. aiding in its stabilization, intracellular trafficking, and enzymatic activity regulation. Structurally, PTPRCAP contains a conserved N-terminal domain for CD45 binding and a C-terminal region involved in protein-protein interactions. Its role in maintaining CD45’s function underscores its importance in immune cell development, antigen receptor signaling, and immune homeostasis. Dysregulation of PTPRCAP has been implicated in autoimmune disorders, immunodeficiency, and leukemia. Researchers use PTPRCAP antibodies in techniques like Western blotting, immunohistochemistry, and flow cytometry to study CD45 complex dynamics, immune cell activation pathways, and disease mechanisms. These antibodies are vital tools for exploring lymphocyte biology and developing therapies targeting immune dysregulation.

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