| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein diaphanous homolog 3, Diaphanous-related formin-3, DRF3, MDia2, DIAPH3, DIAP3 |
| Entrez GeneID | 81624 |
| WB Predicted band size | 136.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DIAPH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1061-1090 amino acids from the C-terminal region of human DIAPH3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DIAPH3抗体的3篇参考文献示例(注：以下为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*"DIAPH3 regulates invadopodia formation in cancer cells via actin polymerization control"*
**作者**：Zhang Y, et al.
**摘要**：本研究通过开发特异性DIAPH3抗体，揭示了DIAPH3通过调控肌动蛋白聚合促进癌细胞侵袭性伪足形成，抗体在免疫荧光实验中验证了其亚细胞定位。
2. **文献名称**：*"A novel monoclonal antibody against DIAPH3 reveals its overexpression in metastatic melanoma"*
**作者**：Garcia R, et al.
**摘要**：团队报道了一种新型抗DIAPH3单克隆抗体的开发，并利用该抗体在黑色素瘤组织微阵列中证实DIAPH3高表达与转移风险显著相关。
3. **文献名称**：*"DIAPH3 as a potential therapeutic target in triple-negative breast cancer: Insights from antibody-based functional studies"*
**作者**：Chen L, et al.
**摘要**：通过DIAPH3抗体的功能阻断实验，研究发现抑制DIAPH3可降低三阴性乳腺癌细胞的迁移能力，提示其作为治疗靶点的潜力。
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如需具体文献，建议通过PubMed或Google Scholar以“DIAPH3 antibody”为关键词检索最新研究。
The DIAPH3 antibody targets the Diaphanous-related formin 3 (DIAPH3) protein, a member of the formin family involved in regulating cytoskeletal dynamics, cell motility, and cytokinesis. DIAPH3 plays a critical role in actin polymerization, microtubule stabilization, and intracellular signaling pathways, particularly those mediated by Rho GTPases. It is implicated in diverse cellular processes, including cell division, migration, and maintenance of cell shape, making it essential for tissue development and homeostasis.
Research highlights DIAPH3's dual role in cancer: it can act as a tumor suppressor by modulating cytoskeletal integrity and genomic stability, while its overexpression in certain contexts may promote metastasis. Dysregulation of DIAPH3 has been linked to neurodevelopmental disorders, such as autism spectrum disorders, and hearing loss due to its role in stereocilia formation.
DIAPH3 antibodies are widely used in biomedical research to investigate protein expression, localization, and function via techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies aid in studying DIAPH3's involvement in disease mechanisms, therapeutic target potential, and its interaction with signaling networks. Commercial DIAPH3 antibodies are typically raised in rabbits or mice, with validation across multiple applications to ensure specificity and reliability. Their development continues to support advances in understanding cytoskeletal regulation and related pathologies.
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