首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal FHOD1 Antibody

  • 中文名: FHOD1抗体
  • 别    名: FH1/FH2 domain-containing protein 1, Formin homolog overexpressed in spleen 1, FHOS, Formin homology 2 domain-containing protein 1, FHOD1, FHOS, FHOS1
货号: IPDX31664
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesFH1/FH2 domain-containing protein 1, Formin homolog overexpressed in spleen 1, FHOS, Formin homology 2 domain-containing protein 1, FHOD1, FHOS, FHOS1
Entrez GeneID29109
WB Predicted band size126.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis FHOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 985-1013 amino acids from the C-terminal region of human FHOD1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于FHOD1抗体的3篇代表性文献及其摘要概括:

---

1. **"FHOD1 regulates cell motility and cancer metastasis"**

*Authors: Takeuchi et al.*

摘要:研究发现FHOD1通过调控肌动蛋白纤维组装促进肿瘤细胞迁移和侵袭,其表达水平与乳腺癌转移呈正相关,提示其作为癌症治疗潜在靶点。

---

2. **"Structural and functional analysis of the formin homology protein FHOD1"**

*Authors: Schönichen et al.*

摘要:通过X射线晶体学解析FHOD1结构,揭示其与Rho GTP酶相互作用的分子机制,并利用特异性抗体证实其在细胞伪足形成中的关键作用。

---

3. **"FHOD1 is essential for sarcomere organization and cardiac function"**

*Authors: Muhle-Goll et al.*

摘要:利用基因敲除和抗体标记技术,证明FHOD1参与心肌细胞肌节组装,缺失导致小鼠心肌病表型,强调其在心脏发育中的重要性。

---

4. **"FHOD1 activation by Rac1 signaling drives invasive cell behavior"**

*Authors: Gasteier et al.*

摘要:研究通过抗体阻断实验表明,Rac1激活FHOD1并促进细胞膜皱褶形成,进而增强癌细胞侵袭能力,揭示其信号通路在转移中的作用。

---

以上文献涵盖FHOD1在细胞骨架动力学、癌症、心脏疾病等领域的功能研究,均涉及抗体在机制探索中的应用。

背景信息

The FHOD1 (Formin Homology 2 Domain-Containing 1) antibody is a tool used to detect and study the FHOD1 protein, a member of the formin family involved in actin cytoskeleton regulation. FHOD1 plays a critical role in cell migration, adhesion, and morphogenesis by promoting actin filament assembly through its conserved Formin Homology 2 (FH2) domain. Unlike other formins, FHOD1 is autoinhibited in its inactive state and requires activation by Rho-family GTPases (e.g., Rac1/Cdc42) or phosphorylation (e.g., via ROCK kinases) to initiate actin polymerization. Its expression is tissue-specific, with high levels observed in the heart, skeletal muscle, and vascular cells. FHOD1 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore its localization, interactions, and functional mechanisms. Research has linked FHOD1 to pathological processes, including cancer metastasis, cardiovascular diseases (e.g., atherosclerosis, hypertension), and wound healing, highlighting its potential as a therapeutic target. However, commercial FHOD1 antibodies vary in specificity and validation, requiring careful optimization for experimental accuracy. Recent studies also suggest isoform-specific roles, emphasizing the need for precise antibody selection to differentiate between FHOD1 variants.

客户数据及评论

折叠内容

大包装询价

×