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Rabbit Polyclonal PRSS16(N-term) Antibody

  • 中文名： PRSS16 (N-term)抗体
  • 别    名： Thymus-specific serine protease, 34--, Serine protease 16, PRSS16, TSSP
货号: IPDX31666
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesThymus-specific serine protease, 34--, Serine protease 16, PRSS16, TSSP
Entrez GeneID10279
WB Predicted band size55.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis PRSS16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the N-terminal region of human PRSS16.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PRSS16(N-term)抗体的参考文献示例(注：文献为模拟示例，实际检索时需核实)：

1. **"Characterization of PRSS16 Protease and Its N-Terminal Antibody in Thymic Epithelial Cells"**

- **作者**: Wang, X. et al. (2008)

- **摘要**: 本研究开发了一种针对PRSS16蛋白N端表位的兔多克隆抗体，并验证其在人胸腺组织中的特异性。通过免疫组化和Western blot证实该抗体能识别内源性PRSS16.揭示了其在胸腺上皮细胞中的定位及表达调控。

2. **"Role of PRSS16 in Immune Tolerance: Insights from N-Terminal Antibody-Based Studies"**

- **作者**: Gommeaux, J. et al. (2010)

- **摘要**: 利用抗PRSS16 N端的抗体，研究团队发现PRSS16通过调控胸腺T细胞选择参与自身免疫耐受。抗体特异性通过PRSS16敲除小鼠模型验证，结果显示其在胸腺基质细胞中的关键功能。

3. **"Development of a Novel PRSS16 (N-Term) Monoclonal Antibody for Cancer Biomarker Screening"**

- **作者**: Sekine, H. et al. (2015)

- **摘要**: 报道了一种高特异性抗PRSS16 N端单克隆抗体的制备，并用于检测多种肿瘤样本中的PRSS16表达。研究显示，PRSS16在肺癌和乳腺癌中显著上调，可能与肿瘤微环境相关。

4. **"PRSS16 Antibody Validation in Autoimmune Disease Models"**

- **作者**: Liu, Y. et al. (2020)

- **摘要**: 通过免疫沉淀和质谱分析验证了抗PRSS16 N端抗体的特异性，并应用于类风湿性关节炎模型研究。结果表明，PRSS16可能通过蛋白酶活性参与炎症通路调控。

**提示**：实际文献需通过PubMed、Google Scholar等平台以关键词“PRSS16 antibody N-terminal”或“PRSS16 protease”检索，并关注抗体开发、验证或功能性研究的论文。部分商业抗体供应商(如Abcam、Sigma-Aldrich)的产品手册也可能引用相关文献。

背景信息

The PRSS16 (N-term) antibody is designed to detect the N-terminal region of PRSS16. a protein encoded by the PRSS16 gene, also known as TSSP (thymus-specific serine protease). PRSS16 belongs to the serine protease family, which is characterized by a catalytic triad of serine, histidine, and aspartic acid residues. This enzyme is predominantly expressed in the thymus, particularly in cortical thymic epithelial cells (cTECs), where it plays a critical role in T-cell development and immune tolerance. PRSS16 is involved in the cleavage of peptides presented by major histocompatibility complex (MHC) class II molecules, influencing positive selection of CD4+ T cells. Dysregulation of PRSS16 has been linked to autoimmune diseases and immunodeficiency disorders. The N-terminal-specific antibody is commonly used in research to study PRSS16 expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal domain ensures recognition of full-length or truncated isoforms, aiding investigations into protein processing or disease-associated mutations. Validation often includes testing in PRSS16-knockout models to confirm antibody reliability.

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