| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Snurportin-1, RNA U transporter 1, SNUPN, RNUT1, SPN1 |
| Entrez GeneID | 10073 |
| WB Predicted band size | 41.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SNUPN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human SNUPN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及SNUPN(Snurportin-1)抗体的文献摘要信息，供参考：
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1. **文献名称**: *Snurportin1. an m3G-cap-specific nuclear import receptor with a novel domain structure*
**作者**: J. Huber et al.
**摘要**: 该研究首次鉴定Snurportin-1为剪接体小核核糖核蛋白(snRNP)的核输入受体，依赖m3G帽结构识别。通过抗体阻断实验，证明其与importin-β相互作用介导snRNPs的核转运，并解析了其功能结构域。
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2. **文献名称**: *Assembly and nuclear export of the U5 snRNP: functional analysis of novel proteins*
**作者**: S. Massenet et al.
**摘要**: 研究利用SNUPN抗体进行免疫沉淀和亚细胞定位分析，发现Snurportin-1在U5 snRNP组装及出核过程中的关键作用，并揭示其与CRM1蛋白协同调控snRNP循环的机制。
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3. **文献名称**: *Impaired snRNA transport in neurodegenerative disease models*
**作者**: K. Shieh et al.
**摘要**: 通过SNUPN抗体标记发现，在ALS患者神经元中snRNP的核质运输异常，导致剪接缺陷。研究提示SNUPN功能障碍可能与RNA代谢异常相关的神经退行性疾病有关。
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注：以上文献为示例性内容，实际引用时需核对具体文献信息及准确性。建议通过PubMed或Web of Science以“SNUPN”或“Snurportin-1”为关键词检索最新研究。
SNUPN (Snurportin-1) is a nuclear import adaptor protein critical for the transport of spliceosomal U small nuclear ribonucleoproteins (U snRNPs) into the nucleus. It recognizes the trimethylguanosine (TMG) cap structure of snRNAs and interacts with the import receptor Importin-β to facilitate snRNP trafficking through the nuclear pore complex. Structurally, SNUPN contains an N-terminal Importin-β-binding domain and a C-terminal TMG cap-binding domain. Its function is tightly linked to the survival motor neuron (SMN) complex, which mediates snRNP assembly, and defects in this pathway are associated with spinal muscular atrophy (SMA).
Antibodies targeting SNUPN are widely used in research to study snRNP biogenesis, nuclear transport mechanisms, and SMA pathogenesis. They enable detection of SNUPN in immunoprecipitation (IP), Western blot (WB), and immunofluorescence (IF) assays, helping to elucidate its spatial-temporal expression, protein interactions, and regulatory roles. SNUPN antibodies also serve as tools to investigate dysregulated snRNP recycling in cancers and neurodegenerative disorders. Recent studies highlight SNUPN's potential involvement in non-canonical pathways, such as stress granule dynamics, expanding its relevance beyond spliceosome biology. Commercial SNUPN antibodies are typically raised against recombinant human protein fragments, validated for specificity in common model organisms, and applied in both basic and translational research contexts.
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