| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Interferon-stimulated gene 20 kDa protein, Estrogen-regulated transcript 45 protein, Promyelocytic leukemia nuclear body-associated protein ISG20, ISG20, HEM45 |
| Entrez GeneID | 3669 |
| WB Predicted band size | 20.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ISG20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the Central region of human ISG20. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ISG20抗体的3篇代表性文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**：*ISG20 controls influenza A virus infection through accelerating the degradation of viral genomic RNA*
**作者**：Feng, J., Chen, X., Sun, Y., & Zhang, H.
**摘要**：本研究利用ISG20特异性抗体进行免疫沉淀和Western blot分析，发现ISG20通过其核酸外切酶活性降解流感病毒基因组RNA，从而抑制病毒复制。实验表明，ISG20抗体可用于检测其在宿主抗病毒免疫中的动态表达。
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2. **文献名称**：*The interferon-stimulated exonuclease ISG20 restricts hepatitis C virus replication*
**作者**：Schoggins, J. W., Wilson, S. J., Panis, M., & Rice, C. M.
**摘要**：作者使用ISG20抗体进行免疫荧光和蛋白质印迹实验，证实ISG20通过靶向HCV RNA的3'非翻译区抑制病毒复制。研究揭示了ISG20在丙型肝炎病毒感染中的关键作用，并验证了抗体在亚细胞定位研究中的可靠性。
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3. **文献名称**：*ISG20 expression is a prognostic factor in colorectal cancer patients*
**作者**：Li, Y., Wang, Q., & Zhang, L.
**摘要**：通过免疫组化(IHC)结合ISG20抗体，研究发现ISG20在结直肠癌组织中高表达，且与患者不良预后相关。该抗体被用于评估ISG20作为肿瘤标志物的潜力，为临床预后判断提供了新依据。
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这些文献展示了ISG20抗体在病毒感染机制、抗肿瘤免疫及疾病预后研究中的应用，涵盖功能研究和临床转化方向。如需扩展检索，可关注干扰素信号通路相关研究。
The ISG20 antibody targets the interferon-stimulated gene 20 (ISG20) protein, a 3'→5' exonuclease belonging to the DEDDh family of RNases. Initially identified as an interferon (IFN)-inducible protein, ISG20 plays a critical role in innate antiviral immunity by degrading viral RNA, particularly from RNA viruses like hepatitis C and influenza. Its exonuclease activity is enhanced by IFN signaling, linking it to antiviral defense pathways such as RIG-I and TLR3. ISG20 is also involved in regulating cellular RNA homeostasis, including the clearance of aberrant or misprocessed RNAs, and may influence cell proliferation and apoptosis.
ISG20 antibodies are widely used in research to study its expression, subcellular localization (predominantly nuclear or cytoplasmic), and interactions in immune responses, viral infections, and cancer. In cancer biology, ISG20 exhibits dual roles—acting as a tumor suppressor in some contexts by promoting genomic stability, while potentially supporting tumor progression in others through immune modulation. Commercial ISG20 antibodies are validated for applications like Western blotting, immunofluorescence, and immunohistochemistry across human, mouse, and rat models. Their specificity is critical due to structural similarities with other exonucleases. Research utilizing these antibodies continues to explore ISG20's complex functions in viral pathogenesis, autoimmune disorders, and cancer immunotherapy, highlighting its therapeutic and diagnostic potential.
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