| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Synaptogyrin-2, Cellugyrin, SYNGR2 |
| Entrez GeneID | 9144 |
| WB Predicted band size | 24.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SYNGR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human SYNGR2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SYNGR2 (N-term)抗体的3篇参考文献示例(注：内容为示例性概括，具体文献需结合实际数据库检索)：
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1. **文献名称**: "SYNGR2 regulates synaptic vesicle trafficking in hippocampal neurons"
**作者**: Smith A, et al. (2018)
**摘要**: 该研究使用SYNGR2 (N-term)抗体通过Western blot和免疫荧光技术，证实了SYNGR2在神经元突触中的定位，并揭示其通过调控囊泡运输影响突触传递功能。
2. **文献名称**: "Overexpression of SYNGR2 correlates with poor prognosis in glioblastoma"
**作者**: Johnson B, et al. (2020)
**摘要**: 通过抗SYNGR2 N端抗体的免疫组化分析，发现胶质母细胞瘤组织中SYNGR2蛋白表达显著升高，且与患者生存期缩短相关，提示其作为潜在肿瘤标志物。
3. **文献名称**: "Development and validation of a specific antibody targeting the N-terminal domain of SYNGR2"
**作者**: Brown C, et al. (2021)
**摘要**: 研究报道了一种针对SYNGR2 N端结构域的高特异性多克隆抗体的开发，验证了其在免疫印迹、免疫沉淀及免疫细胞化学中的应用，为相关疾病研究提供工具。
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**提示**：如需真实文献，建议通过PubMed或Google Scholar检索关键词“SYNGR2 antibody N-terminal”，并结合抗体生产商(如Abcam、Santa Cruz)提供的引用文献列表获取具体信息。
The SYNGR2 (N-term) antibody targets the N-terminal region of Synaptogyrin-2 (SYNGR2), a member of the synaptogyrin family implicated in synaptic vesicle dynamics and neurotransmitter release. SYNGR2 is a transmembrane protein enriched in neuronal and endocrine tissues, where it localizes to synaptic vesicles and secretory granules. It interacts with components of the exocytotic machinery, potentially modulating vesicle trafficking, fusion, or recycling.
Studies suggest SYNGR2 may play roles in neurodevelopment, synaptic plasticity, and neurological disorders. Altered expression or mutations in SYNGR2 have been loosely associated with schizophrenia, autism spectrum disorders, and intellectual disabilities, though its precise mechanistic contributions remain under investigation. The N-terminal domain is critical for its intracellular sorting and protein-protein interactions, making antibodies against this region valuable tools for studying SYNGR2's localization, expression levels, and molecular interactions.
The SYNGR2 (N-term) antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to probe protein expression patterns in brain tissues, cultured neurons, or model organisms. Validation typically includes testing in knockout models or siRNA-treated samples to confirm specificity. Its applications span basic neuroscience research, disease biomarker studies, and drug development pipelines targeting synaptic dysfunction.
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