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Rabbit Polyclonal DEF6 Antibody

  • 中文名: DEF6抗体
  • 别    名: Differentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, DEF6, IBP
货号: IPDX31660
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDifferentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, DEF6, IBP
Entrez GeneID50619
WB Predicted band size73.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis DEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-528 amino acids from the C-terminal region of human DEF6.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于DEF6抗体的示例参考文献(注:以下内容为模拟示例,非真实文献):

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1. **标题**: *"DEF6 regulates T-cell synapse formation and immune activation through cytoskeletal remodeling"*

**作者**: Smith A, et al.

**摘要**: 研究使用DEF6特异性抗体探究其在T细胞突触形成中的作用,发现DEF6通过调控肌动蛋白重组促进免疫突触成熟,缺陷导致T细胞活化受损。

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2. **标题**: *"Autoimmunity in DEF6-deficient mice correlates with altered B-cell signaling"*

**作者**: Chen L, et al.

**摘要**: 通过DEF6抗体检测基因敲除小鼠模型,发现DEF6缺失导致B细胞过度活化及自身抗体产生,提示其在抑制系统性自身免疫中的关键作用。

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3. **标题**: *"Elevated DEF6 expression in lupus nephritis patients links to disease severity"*

**作者**: Gupta R, et al.

**摘要**: 利用DEF6抗体进行组织染色,发现系统性红斑狼疮(SLE)患者肾脏中DEF6蛋白表达升高,与炎症因子水平正相关,提示其作为疾病生物标志物的潜力。

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4. **标题**: *"DEF6 interacts with SWAP-70 to modulate RAC1 signaling in dendritic cells"*

**作者**: Müller T, et al.

**摘要**: 通过免疫共沉淀(使用DEF6抗体)揭示DEF6与SWAP-70协同调控树突状细胞迁移的机制,为靶向免疫细胞迁移的治疗提供新思路。

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(注:以上文献为模拟生成,实际研究中请通过学术数据库核实具体参考文献。)

背景信息

The DEF6 (Differentially Expressed in FDCP 6) protein, also known as IBAT or SWAP-70-like adapter of T cells, is a guanine nucleotide exchange factor (GEF) involved in immune regulation. It shares structural and functional similarities with SWAP-70. containing a pleckstrin homology (PH) domain, coiled-coil regions, and a catalytic Dbl homology (DH) domain that activates Rho GTPases like Rac1 and Cdc42. DEF6 plays critical roles in T-cell activation, cytokine production (e.g., IL-17), and Th17 cell differentiation by coordinating cytoskeletal dynamics and signaling pathways. Dysregulation of DEF6 is linked to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. DEF6-targeting antibodies are essential tools for studying its expression, localization, and interactions in immune cells. Recent studies highlight its therapeutic potential; for example, anti-DEF6 antibodies have been explored in preclinical models to modulate aberrant immune responses. These antibodies also aid in elucidating DEF6’s dual role as both an oncogene and tumor suppressor in different cancers. Research continues to unravel its context-dependent signaling mechanisms, emphasizing its importance in immune homeostasis and disease pathogenesis.

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