| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dead end protein homolog 1, RNA-binding motif, single-stranded-interacting protein 4, DND1, RBMS4 |
| Entrez GeneID | 373863 |
| WB Predicted band size | 38.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the Central region of human DND1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DND1抗体的3篇参考文献示例(注：文献为模拟示例，具体内容请根据实际研究调整)：
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1. **文献名称**：*DND1 maintains germline stem cells via interaction with miRNA targets*
**作者**：Young, R.A. et al.
**摘要**：研究利用DND1特异性抗体通过免疫共沉淀和Western blot技术，揭示了DND1蛋白通过与miRNA靶标结合维持生殖干细胞的自我更新能力，缺失DND1会导致生殖细胞凋亡增加。
2. **文献名称**：*Loss of DND1 expression promotes testicular teratoma progression*
**作者**：Suzuki, H. et al.
**摘要**：通过免疫组化(使用DND1多克隆抗体)分析发现，DND1在睾丸畸胎瘤中表达显著下调，其缺失与肿瘤侵袭性增强相关，提示DND1可能作为生殖细胞肿瘤的抑制因子。
3. **文献名称**：*DND1 is essential for early embryonic development in mice*
**作者**：Kim, J. & Lee, Y.
**摘要**：研究利用DND1抗体进行胚胎组织免疫荧光染色，证明DND1在小鼠早期胚胎发育中不可或缺，敲除后导致胚胎停滞并伴随多能性标记基因异常表达。
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如需具体文献，建议通过PubMed或Google Scholar以“DND1 antibody”为关键词检索，并筛选涉及抗体应用的实验研究(如Western blot、免疫组化等)。
DND1 (Dead-End Homolog 1) is an RNA-binding protein critical for germ cell development and maintaining pluripotency in stem cells. Initially identified in zebrafish (as Dnd), it plays a conserved role in vertebrates by stabilizing target mRNAs and regulating their translation, thereby ensuring germline integrity and preventing premature differentiation. In mammals, DND1 is highly expressed in primordial germ cells (PGCs) and gonads, where it suppresses apoptosis and promotes survival by counteracting miRNA-mediated mRNA degradation. Mutations or dysregulation of DND1 are linked to human infertility, germ cell tumors (e.g., testicular teratomas), and impaired embryonic development.
DND1 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blot, immunohistochemistry, and immunofluorescence to investigate DND1's role in germ cell biology, stem cell regulation, and cancer. Research using these antibodies has revealed DND1's involvement in RNA-protein complexes, its interaction with miRNAs, and its function in epigenetic regulation. Additionally, DND1 antibodies aid in exploring its potential as a biomarker for germ cell malignancies or reproductive disorders. Their application continues to advance understanding of post-transcriptional gene regulation in development and disease.
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