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Rabbit Polyclonal CCDC141(N-term) Antibody

  • 中文名： CCDC141 (N-term)抗体
  • 别    名： Coiled-coil domain-containing protein 141, Coiled-coil protein associated with myosin II and DISC1, CCDC141, CAMDI {ECO:0000303|PubMed:20956536}
货号: IPDX31658
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCoiled-coil domain-containing protein 141, Coiled-coil protein associated with myosin II and DISC1, CCDC141, CAMDI {ECO:0000303|PubMed:20956536}
Entrez GeneID285025
WB Predicted band size166.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CCDC141 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCDC141.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CCDC141(N-term)抗体的3篇参考文献的简要信息：

1. **文献名称**: *"CCDC141 is required for acrosome biogenesis and sperm head shaping in mice"*

**作者**: Li W, et al.

**摘要**: 该研究利用针对CCDC141 N端结构域的多克隆抗体(兔源)，通过免疫荧光和Western blot技术，揭示了CCDC141在小鼠精子顶体形成和头部形态发生中的关键作用。研究表明，CCDC141缺失导致精子畸形和不育。

2. **文献名称**: *"The role of CCDC141 in ciliogenesis and cellular migration"*

**作者**: Smith J, et al.

**摘要**: 作者开发了靶向CCDC141 N末端的特异性抗体(小鼠单克隆)，用于免疫组化分析。研究发现CCDC141通过调控纤毛基体蛋白运输影响细胞迁移，在纤毛病相关通路中发挥重要作用。

3. **文献名称**: *"Proteomic characterization of the sperm fibrous sheath identifies CCDC141 as a diagnostic marker"*

**作者**: Chen X, et al.

**摘要**: 该研究通过N端特异性抗体(山羊多克隆)进行免疫电镜定位，证实CCDC141定位于精子纤维鞘结构，并验证其作为男性不育潜在生物标志物的价值，为临床诊断提供新思路。

注：上述文献为示例，若需真实文献，建议通过PubMed或Google Scholar检索关键词“CCDC141 antibody N-terminal”或结合基因功能(如纤毛、精子发生)筛选近期研究。部分公司抗体产品手册(如Abcam、Sigma)也可能引用相关文献。

背景信息

The CCDC141 (N-term) antibody is a research tool designed to target the N-terminal region of the coiled-coil domain-containing protein 141 (CCDC141), a gene implicated in diverse cellular processes. CCDC141 encodes a large protein with multiple coiled-coil domains, suggesting roles in cytoskeletal organization, intracellular transport, or cell signaling. Studies link CCDC141 to neuroendocrine functions, reproductive biology, and cilia-related pathways, with mutations associated with conditions like Kallmann syndrome (a genetic disorder affecting puberty and olfaction) and primary ciliary dyskinesia. The antibody’s specificity for the N-terminal region allows detection of full-length CCDC141 isoforms, distinguishing them from potential truncated variants. It is commonly used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study CCDC141 expression, localization, and interactions in tissues like the brain, testes, and ciliated epithelia. Recent research highlights its utility in exploring CCDC141’s involvement in neuronal migration, hypothalamic development, and spermatogenesis. Validation typically includes knockout cell lines or tissues to confirm signal specificity. As CCDC141’s mechanistic roles remain under investigation, this antibody serves as a critical reagent for deciphering its biological and pathological significance.

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