| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Prosaposin receptor GPR37L1, Endothelin B receptor-like protein 2, ETBR-LP-2, G-protein coupled receptor 37-like 1, GPR37L1, ETBRLP2 |
| Entrez GeneID | 9283 |
| WB Predicted band size | 52.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GPR37L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human GPR37L1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GPR37L1(N-term)抗体的3篇代表性文献示例(注：以下为基于领域知识的模拟内容，实际文献需通过数据库验证)：
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1. **文献名称**：*"Characterization of GPR37L1 expression in the mammalian brain using a novel N-terminal antibody"*
**作者**：Smith A et al.
**摘要**：本研究开发并验证了一种针对GPR37L1 N端表位的多克隆抗体，通过免疫印迹和免疫组化证实其在啮齿类及人脑组织中的特异性。抗体成功定位GPR37L1于星形胶质细胞，提示其在中枢神经系统的潜在功能。
2. **文献名称**：*"GPR37L1 modulates Wnt/β-catenin signaling in glioblastoma: Insights from antibody-mediated detection"*
**作者**：Chen L et al.
**摘要**：利用抗GPR37L1(N-term)抗体，研究发现该受体在胶质母细胞瘤细胞中高表达，并通过与Wnt通路互作促进肿瘤侵袭。抗体特异性通过siRNA敲减实验验证，支持其作为癌症生物标志物的潜力。
3. **文献名称**：*"Validation of a commercial GPR37L1 antibody for neurodegenerative disease research"*
**作者**：Kimura T et al.
**摘要**：系统评估了市售GPR37L1 N端抗体的可靠性，发现其在帕金森病模型小鼠脑组织中可检测到受体表达下调。通过对比GPR37L1敲除小鼠组织，确认抗体无交叉反应性，强调其在神经退行性疾病研究中的实用性。
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如需具体文献，建议在 **PubMed** 或 **Google Scholar** 中检索关键词：
`GPR37L1 antibody N-terminal`, `GPR37L1 epitope validation`, `GPR37L1 immunohistochemistry`。
The GPR37L1 (N-term) antibody is a specialized tool designed to target the N-terminal region of GPR37L1. an orphan G protein-coupled receptor (GPCR) predominantly expressed in the central nervous system, particularly in astrocytes and oligodendrocytes. GPR37L1 shares structural homology with GPR37. another orphan receptor linked to Parkinson’s disease, though their functions remain incompletely understood. Research suggests GPR37L1 may regulate neuroprotection, myelination, and ion homeostasis, with potential roles in modulating synaptic activity and response to cellular stress. Its involvement in neurological disorders, such as glioma and epilepsy, has sparked interest in studying its signaling mechanisms.
The N-terminal-specific antibody enables detection of GPR37L1 in various experimental applications, including Western blotting, immunohistochemistry, and immunofluorescence, aiding in mapping its expression patterns and post-translational modifications. Validating antibody specificity is critical due to the receptor’s low abundance and homology with GPR37. Studies using this antibody have highlighted differential expression of GPR37L1 in disease models, suggesting its utility as a biomarker or therapeutic target. Ongoing research aims to deorphanize GPR37L1 by identifying its ligands and downstream pathways, which could unlock insights into its physiological and pathological roles within the brain.
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