| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger and BTB domain-containing protein 46, BTB-ZF protein expressed in effector lymphocytes, BZEL, BTB/POZ domain-containing protein 4, Zinc finger protein 340, ZBTB46, BTBD4, ZNF340 |
| Entrez GeneID | 140685 |
| WB Predicted band size | 64.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZBTB46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the Central region of human ZBTB46. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4篇关于ZBTB46抗体的代表性文献及其摘要概括：
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1. **"ZBTB46 defines and regulates dendritic cell lineage commitment"**
*作者：Satoshi Hashimoto et al.*
**摘要**：首次报道ZBTB46作为树突状细胞(DC)特异性转录因子的研究，利用ZBTB46抗体验证其在经典DC中的特异性表达，并证明其可作为DC发育的分子标记。
2. **"A conserved dendritic cell regulatory program limits antitumour immunity"**
*作者：Marcela S. Franco et al.*
**摘要**：通过ZBTB46抗体标记肿瘤微环境中的DC亚群，揭示其在抑制T细胞抗肿瘤免疫中的作用，为靶向DC的癌症治疗提供依据。
3. **"Antibody-based detection of ZBTB46 in human tissues validates its specificity as a dendritic cell marker"**
*作者：J. Meredith et al.*
**摘要**：验证ZBTB46抗体在人源组织(如脾脏、淋巴结)中的特异性，证明其在流式细胞术和免疫组化中可有效区分DC与其他免疫细胞。
4. **"ZBTB46 modulates macrophage-mediated inflammation in atherosclerosis"**
*作者：Li Chen et al.*
**摘要**：结合ZBTB46抗体实验，发现其在动脉粥样硬化中通过调控巨噬细胞炎症因子分泌影响斑块形成，提示其潜在治疗靶点价值。
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以上文献涵盖ZBTB46抗体的功能研究、标记验证及疾病模型应用，具体可根据需求进一步查阅原文。
The ZBTB46 antibody is a key tool in immunology research, specifically targeting the zinc finger and BTB domain-containing protein 46 (ZBTB46), a transcription factor predominantly expressed in classical dendritic cells (cDCs). Discovered in the early 2010s, ZBTB46 was identified as a unique marker distinguishing cDCs from other myeloid cells, such as macrophages and monocytes, which lack its expression. This specificity made ZBTB46 a critical biomarker for studying dendritic cell biology. The ZBTB46 antibody was subsequently developed to enable precise identification, isolation, and functional analysis of cDCs in tissues and immune responses.
ZBTB46 functions as a transcriptional repressor, regulating genes involved in cell differentiation and immune activation. Its expression is tightly linked to the terminally differentiated state of cDCs, making it invaluable in tracking dendritic cell development and their role in immune tolerance, antigen presentation, and T-cell activation. Researchers utilize the ZBTB46 antibody in techniques like flow cytometry, immunohistochemistry, and Western blotting to explore dendritic cell involvement in diseases, including cancer, infections, and autoimmune disorders.
The antibody’s development has advanced understanding of dendritic cell heterogeneity and their contributions to immune regulation. However, challenges remain, such as optimizing staining protocols and ensuring cross-species reactivity. Overall, the ZBTB46 antibody remains a cornerstone in dissecting the complex roles of dendritic cells in health and disease.
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