| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein Wnt-6, WNT6 |
| Entrez GeneID | 7475 |
| WB Predicted band size | 39.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This WNT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-201 amino acids from the Central region of human WNT6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于WNT6抗体的3篇参考文献示例(文献信息为模拟，仅供参考)：
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1. **文献名称**: *WNT6 regulates epidermal stem cell proliferation and differentiation during skin regeneration*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性WNT6抗体，通过免疫组化分析发现WNT6在皮肤损伤修复中高表达，并通过调控β-catenin通路促进表皮干细胞增殖与分化，为组织再生机制提供新见解。
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2. **文献名称**: *Role of WNT6 in colorectal cancer progression and its interaction with tumor microenvironment*
**作者**: Chen L, et al.
**摘要**: 通过Western blot和免疫荧光技术结合WNT6抗体，证实WNT6在结直肠癌组织中过表达，且与肿瘤侵袭性正相关。研究揭示了WNT6通过激活非经典WNT信号通路促进癌细胞迁移的机制。
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3. **文献名称**: *Developmental expression of WNT6 in the nervous system: Insights from antibody-based localization*
**作者**: García-Ruiz C, et al.
**摘要**: 使用高特异性WNT6抗体对小鼠胚胎神经组织进行分析，发现WNT6在脊髓背侧区域特异性表达，提示其可能参与背侧神经元分化和神经管模式形成的调控。
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如需具体文献全文或更多研究，建议通过PubMed或Sci-Hub等平台检索标题或作者名。
**Background of WNT6 Antibody**
The WNT6 antibody is a tool used to detect WNT6. a member of the Wnt family of secreted glycoproteins. Wnt proteins play critical roles in embryonic development, tissue homeostasis, and cell signaling by regulating processes such as cell proliferation, differentiation, and polarity. WNT6 specifically is involved in β-catenin-dependent (canonical) and -independent (non-canonical) signaling pathways. It contributes to organogenesis, including limb, kidney, and nervous system development, and is implicated in maintaining stem cell niches. Dysregulation of WNT6 has been linked to diseases such as cancer, skeletal disorders, and neurodegenerative conditions.
WNT6 antibodies are designed to recognize epitopes specific to the WNT6 protein, enabling its detection in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence. These antibodies are essential for studying WNT6 expression patterns, localization, and interactions in biological samples. Researchers utilize them to explore WNT6's role in developmental biology, disease mechanisms, and potential therapeutic targeting.
Validation of WNT6 antibodies is crucial, as cross-reactivity with other Wnt family members (e.g., WNT1. WNT3A) can occur due to structural similarities. Antibodies are typically raised in hosts like rabbits or mice, with specificity confirmed via knockout controls or siRNA-mediated gene silencing. Commercial WNT6 antibodies often provide data sheets detailing their applications, species reactivity, and recommended experimental conditions. Proper controls and validation remain critical to ensure reliable results in studies involving WNT6 signaling.
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