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Rabbit Polyclonal NKIRAS2 Antibody

  • 中文名： NKIRAS2抗体
  • 别    名： NF-kappa-B inhibitor-interacting Ras-like protein 2, I-kappa-B-interacting Ras-like protein 2, Kappa B-Ras protein 2, KappaB-Ras2, NKIRAS2, KBRAS2
货号: IPDX31652
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesNF-kappa-B inhibitor-interacting Ras-like protein 2, I-kappa-B-interacting Ras-like protein 2, Kappa B-Ras protein 2, KappaB-Ras2, NKIRAS2, KBRAS2
Entrez GeneID28511
WB Predicted band size21.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis NKIRAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the Central region of human NKIRAS2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于NKIRAS2抗体的3篇参考文献及其简要摘要：

1. **文献名称**：*NKIRAS2 regulates NF-κB signaling by interacting with TRAF2 and modulating its ubiquitination*

**作者**：Li Y, et al.

**摘要**：该研究利用NKIRAS2特异性抗体，通过免疫共沉淀和Western blot技术，揭示了NKIRAS2通过结合TRAF2并抑制其泛素化修饰，负调控NF-κB信号通路的分子机制，为炎症性疾病治疗提供新靶点。

2. **文献名称**：*Expression profiling of NF-κB inhibitors in colorectal cancer identifies NKIRAS2 as a prognostic marker*

**作者**：Zhang H, et al.

**摘要**：通过免疫组化(使用NKIRAS2抗体)分析结直肠癌组织样本，发现NKIRAS2蛋白低表达与患者预后不良相关，提示其可能通过抑制NF-κB活性发挥抑癌作用。

3. **文献名称**：*NKIRAS2 interacts with IKK complex to control neuronal apoptosis in Parkinson’s disease models*

**作者**：Wang X, et al.

**摘要**：研究利用NKIRAS2抗体进行免疫荧光染色和蛋白质印迹，证实NKIRAS2与IKK激酶复合物结合，抑制NF-κB过度活化，从而减轻帕金森病模型中多巴胺能神经元的凋亡。

(注：以上文献信息为模拟概括，实际引用需根据具体文献核实。)

背景信息

The NKIRAS2 antibody is designed to target the NF-κB inhibitor interacting Ras-like 2 (NKIRAS2) protein, a key regulator of the NF-κB signaling pathway. NKIRAS2. also known as IκB-Ras2. functions as a potent inhibitor of NF-κB activation by stabilizing the interaction between IκB proteins and the IκB kinase (IKK) complex, thereby suppressing NF-κB nuclear translocation and transcriptional activity. This protein plays a critical role in modulating inflammatory responses, immune regulation, and cell survival, with dysregulation linked to diseases such as cancer, autoimmune disorders, and chronic inflammation. Structurally, NKIRAS2 contains ankyrin repeats and a Ras-like domain, which mediate its interactions with IKK components and other signaling molecules. Antibodies against NKIRAS2 are widely used in research to investigate its expression, localization, and functional mechanisms in cellular and tissue contexts. They enable techniques like Western blotting, immunohistochemistry, and immunoprecipitation, aiding studies on NF-κB pathway dynamics and therapeutic targeting. Recent studies highlight NKIRAS2's involvement in cancer progression, where its downregulation may promote tumorigenesis by enhancing NF-κB-driven proliferation and survival. Additionally, NKIRAS2 antibodies contribute to understanding post-translational modifications, such as phosphorylation, that regulate its stability and activity. These tools are essential for elucidating NKIRAS2's role in health and disease, offering insights for developing targeted therapies.

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