| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Putative phospholipase B-like 2, 311-, 76 kDa protein, p76, LAMA-like protein 2, Lamina ancestor homolog 2, Phospholipase B domain-containing protein 2, Putative phospholipase B-like 2 32 kDa form, Putative phospholipase B-like 2 45 kDa form, PLBD2 |
| Entrez GeneID | 196463 |
| WB Predicted band size | 65.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PLBD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-203 amino acids from the Central region of human PLBD2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PLBD2抗体的3篇参考文献，基于公开信息整理：
1. **文献名称**：*PLBD2 as a Novel Prognostic Biomarker in Hepatocellular Carcinoma*
**作者**：Li, X. et al.
**摘要**：该研究通过免疫组化分析发现PLBD2在肝癌组织中高表达，与患者预后不良相关。使用PLBD2抗体验证其蛋白表达水平，并探讨其通过调控炎症信号通路促进肿瘤进展的机制。
2. **文献名称**：*Characterization of PLBD2 in Neutrophil Extracellular Traps Formation*
**作者**：Wang, Y. et al.
**摘要**：研究利用PLBD2特异性抗体进行Western blot和流式细胞术，证明PLBD2在嗜中性粒细胞活化中上调，并参与细胞外诱捕网(NETs)的形成，可能影响先天免疫反应。
3. **文献名称**：*PLBD2 Regulates Lipid Metabolism in Adipocytes via β-Oxidation*
**作者**：Zhang, R. et al.
**摘要**：通过PLBD2抗体敲低实验发现，PLBD2通过调节脂肪酸β-氧化途径影响脂肪细胞代谢，可能成为代谢综合征的潜在治疗靶点。
**备注**：PLBD2研究仍处于早期阶段，以上内容为模拟示例。建议通过PubMed或Google Scholar以“PLBD2 antibody”或“Phospholipase B domain-containing 2”为关键词检索最新文献。
The phospholipase B domain-containing 2 (PLBD2) antibody is a tool used to detect and study the PLBD2 protein, a member of the PLBD family characterized by conserved phospholipase B-like domains. PLBD2 is implicated in lipid metabolism and membrane remodeling, though its precise enzymatic activity remains unclear. It is expressed in various tissues, including immune cells, and has been linked to inflammatory responses, cellular signaling, and cancer progression. Studies suggest PLBD2 may regulate neutrophil activation and interact with immune-related pathways, making it a potential biomarker for inflammatory diseases. In cancer, PLBD2 overexpression correlates with tumor aggressiveness and poor prognosis in certain malignancies, such as glioblastoma and colorectal cancer.
PLBD2 antibodies are essential for investigating the protein's localization, expression levels, and functional roles. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze tissue-specific distribution or disease-associated alterations. Commercially available PLBD2 antibodies are typically raised in rabbits or mice, targeting specific epitopes within its N-terminal or C-terminal regions. Validation for specificity and cross-reactivity is critical due to structural similarities within the PLBD family. Ongoing research aims to clarify PLBD2's mechanistic contributions to disease pathways, potentially guiding therapeutic targeting or diagnostic applications.
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