| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Palmitoyltransferase ZDHHC3, Protein DHHC1, Zinc finger DHHC domain-containing protein 3, DHHC-3, Zinc finger protein 373, ZDHHC3, ZNF373 |
| Entrez GeneID | 51304 |
| WB Predicted band size | 34.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZDHC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ZDHC3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于ZDHHC3(N-term)抗体的示例参考文献，内容基于典型研究场景的合理推测：
---
1. **文献名称**: "ZDHHC3-Specific Antibody Development and Its Application in Breast Cancer Progression"
**作者**: Zhang Y, et al.
**摘要**: 本研究开发了一种针对ZDHHC3 N端表位的多克隆抗体，通过免疫印迹和免疫组化验证其特异性。实验表明，ZDHHC3在乳腺癌组织中高表达，并与其棕榈酰化底物EGFR的活性调控相关，提示其在肿瘤转移中的潜在作用。
2. **文献名称**: "Localization of ZDHHC3 in Neuronal Synapses Using a Novel N-Terminal Antibody"
**作者**: Greaves J, Chamberlain LH
**摘要**: 文章描述了一种新型抗ZDHHC3 N端抗体在小鼠脑组织中的应用。通过免疫荧光和电镜技术，作者发现ZDHHC3主要富集于突触后膜，调控突触蛋白的棕榈酰化修饰，影响神经信号传递。
3. **文献名称**: "ZDHHC3-Mediated Palmitoylation of RAS Oncoproteins: Insights from Antibody-Based Inhibition Studies"
**作者**: Runkle KB, et al.
**摘要**: 研究利用ZDHHC3(N-term)抗体阻断其功能，发现ZDHHC3通过棕榈酰化修饰RAS蛋白，影响其膜定位及下游MAPK信号通路。该抗体为探索ZDHHC3在癌症中的机制提供了关键工具。
---
**注意**：以上文献为示例性内容，实际研究中请通过PubMed、Web of Science等平台检索真实文献。如需精准文献，建议结合具体研究背景进一步筛选。
The ZDHC3 (N-term) antibody is designed to target the N-terminal region of the ZDHC3 protein, a member of the DHHC (Asp-His-His-Cys) palmitoyltransferase family. ZDHC3. also known as ZDHHC3. is a transmembrane enzyme that catalyzes protein palmitoylation, a post-translational modification critical for membrane anchoring, protein trafficking, and signal transduction. This antibody is commonly used in research to study ZDHC3 expression, localization, and function in cellular processes.
Studies suggest ZDHC3 plays roles in neuronal development, synaptic plasticity, and cancer progression by regulating substrates like SNAP-25. PSD-95. and oncoproteins. Its dysregulation is linked to neurological disorders (e.g., Huntington’s disease) and tumor metastasis. The ZDHC3 (N-term) antibody, typically validated in applications like Western blotting, immunofluorescence, and immunoprecipitation, helps identify protein interactions and post-translational dynamics.
Developed in hosts like rabbit or mouse, it exhibits specificity for human, mouse, or rat ZDHC3. depending on the clone. Researchers rely on this tool to explore ZDHC3’s regulatory mechanisms in disease models, aiding therapeutic target discovery. Proper controls (e.g., knockout validation) are essential to confirm antibody specificity due to potential cross-reactivity with homologous DHHC family members.
×
