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Rabbit Polyclonal SFTPA1B Antibody

  • 中文名： SFTPA1B抗体
  • 别    名： Pulmonary surfactant-associated protein A1, PSP-A, PSPA, SP-A, SP-A1, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-4, SFTPA1, COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B
货号: IPDX31487
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPulmonary surfactant-associated protein A1, PSP-A, PSPA, SP-A, SP-A1, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-4, SFTPA1, COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B
Entrez GeneID653509
WB Predicted band size26.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis SFTPA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-174 amino acids from the Central region of human SFTPA1B.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SFTPA1B抗体的虚构参考文献示例，仅供参考：

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1. **文献名称**：*Characterization of SFTPA1B-Specific Monoclonal Antibodies for Pulmonary Surfactant Research*

**作者**：Chen L, et al.

**摘要**：本研究开发并验证了针对SFTPA1B蛋白的单克隆抗体，通过免疫印迹和免疫组化证实其特异性，为肺表面活性蛋白功能研究提供了可靠工具。

2. **文献名称**：*SFTPA1B Antibody as a Biomarker in Idiopathic Pulmonary Fibrosis*

**作者**：Martinez G, et al.

**摘要**：通过ELISA检测患者血清中SFTPA1B抗体水平，发现其与特发性肺纤维化严重程度显著相关，提示其作为疾病进展的生物标志物潜力。

3. **文献名称**：*Impact of SFTPA1B Gene Mutations on Antibody Recognition in Neonatal Lung Disease*

**作者**：Suzuki K, et al.

**摘要**：分析SFTPA1B基因突变导致蛋白结构改变，发现特定突变会降低商用抗体的结合效率，强调突变验证在临床检测中的重要性。

4. **文献名称**：*Functional Role of SFTPA1B in Innate Immunity: Insights from Antibody Blockade Experiments*

**作者**：Wang H, et al.

**摘要**：利用SFTPA1B特异性抗体阻断实验，证明该蛋白通过调节肺泡巨噬细胞活性在宿主防御中起关键作用。

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注：以上文献为示例性质，实际研究中请通过学术数据库(如PubMed)检索真实文献。

背景信息

The SFTPA1B antibody targets Surfactant Protein A1 (SP-A1), a critical component of pulmonary surfactant produced primarily by alveolar type II cells. Encoded by the SFTPA1 gene, SP-A1 belongs to the collectin family, playing a key role in innate lung immunity by opsonizing pathogens, enhancing phagocytosis, and modulating inflammatory responses. It also contributes to surfactant homeostasis by interacting with lipid membranes. SFTPA1B likely refers to an antibody specific to SP-A1 isoforms or genetic variants, given SFTPA1's known polymorphisms linked to respiratory diseases. Research using SFTPA1B antibodies focuses on understanding SP-A1's involvement in conditions like idiopathic pulmonary fibrosis (IPF), acute respiratory distress syndrome (ARDS), and infections. These antibodies are employed in techniques such as Western blot, immunohistochemistry, and ELISA to study protein expression, localization, and disease mechanisms. Commercial SFTPA1B antibodies are often validated for reactivity in human and animal models, aiding translational studies. Dysregulation of SP-A1 is associated with alveolar proteinosis and chronic lung diseases, making this antibody a valuable tool for both diagnostic and experimental applications in respiratory biology.

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