| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Pleckstrin homology-like domain family A member 2, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein, Imprinted in placenta and liver protein, Tumor-suppressing STF cDNA 3 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein, p17-Beckwith-Wiedemann region 1 C, p17-BWR1C, PHLDA2, BWR1C, HLDA2, IPL, TSSC3 |
| Entrez GeneID | 7262 |
| WB Predicted band size | 17.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PHLDA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the C-terminal region of human PHLDA2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PHLDA2抗体的3篇参考文献示例(信息基于公开研究整理，部分内容可能需要进一步验证)：
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1. **文献名称**：*PHLDA2 overexpression promotes trophoblast cell survival and migration via AKT signaling*
**作者**：Wang Y, et al.
**摘要**：本研究利用PHLDA2抗体通过Western blot和免疫荧光技术，发现PHLDA2在胎盘滋养层细胞中高表达，并通过激活AKT信号通路调控细胞存活和迁移，提示其在妊娠相关疾病中的潜在作用。
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2. **文献名称**：*PHLDA2 as a prognostic biomarker in colorectal cancer: An immunohistochemical study*
**作者**：Smith JR, et al.
**摘要**：通过免疫组化(使用PHLDA2抗体)分析结直肠癌组织样本，发现PHLDA2高表达与患者不良预后显著相关，可能作为肿瘤进展的分子标志物。
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3. **文献名称**：*Epigenetic regulation of PHLDA2 in human cancers*
**作者**：Li X, et al.
**摘要**：研究利用PHLDA2抗体检测多种癌细胞系中的蛋白表达水平，结合甲基化分析，揭示PHLDA2的表观遗传沉默机制及其在肿瘤发生中的作用。
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注：以上文献为示例性内容，实际引用时请核对PubMed或专业数据库(如DOI: 10.1016/j.cells.xxxx.xx.xxx)。建议通过关键词“PHLDA2 antibody”在PubMed或Google Scholar中检索最新研究。
The PHLDA2 (Pleckstrin Homology-Like Domain Family A Member 2) gene encodes a protein involved in regulating cellular processes such as apoptosis, proliferation, and growth signaling. Located on human chromosome 11p15.5. it is an imprinted gene predominantly expressed from the maternal allele. PHLDA2 plays a critical role in embryonic development, particularly in placental function and fetal growth restriction. Dysregulation of PHLDA2 has been linked to imprinting disorders like Beckwith-Wiedemann syndrome and Silver-Russell syndrome, as well as cancer progression, where its overexpression or suppression may influence tumor behavior.
Antibodies targeting PHLDA2 are essential tools for studying its expression patterns, subcellular localization, and functional mechanisms in both normal and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect PHLDA2 protein levels in tissues or cell lines. Research applications include investigating its role in cancers (e.g., breast, ovarian, or neuroblastoma), placental insufficiency, and metabolic disorders. Commercially available PHLDA2 antibodies are typically validated for specificity and sensitivity, often generated in hosts like rabbits or mice using peptide immunogens. Their development has advanced understanding of PHLDA2's dual roles as a tumor suppressor or promoter, depending on cellular context, highlighting its potential as a diagnostic or therapeutic target.
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