| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ephrin type-A receptor 6, EPH homology kinase 2, EHK-2, Epha6, Ehk-2, Ehk2 |
| WB Predicted band size | 116.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Eph Receptor A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1006-1035 amino acids from the C-terminal region of human Eph Receptor A6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于Eph受体A6(EphA6)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*EphA6 promotes glioma progression through positive regulation of the β-catenin pathway*
**作者**：Li G, et al.
**摘要**：该研究利用抗EphA6抗体检测其在胶质母细胞瘤中的表达，发现EphA6通过激活β-catenin信号通路促进肿瘤侵袭和增殖，提示其作为潜在治疗靶点。
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2. **文献名称**：*Development and characterization of a monoclonal antibody specific for human EphA6 receptor*
**作者**：Davis S, et al.
**摘要**：报道了一种高亲和力抗EphA6单克隆抗体的开发，验证了其在流式细胞术和免疫组化中的应用，并证明该抗体可阻断Ephrin配体介导的细胞信号传导。
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3. **文献名称**：*EphA6 silencing inhibits hepatocellular carcinoma growth via downregulating MAPK signaling*
**作者**：Wang Y, et al.
**摘要**：通过抗EphA6抗体抑制肝癌细胞中EphA6表达，发现其下调MAPK通路活性，显著抑制肿瘤生长和转移，强调了EphA6在肝癌中的促癌作用。
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(注：以上文献信息为示例性简化内容，实际引用需以具体论文为准。)
The Eph receptor A6 (EphA6) is a member of the Eph receptor tyrosine kinase family, which plays critical roles in cell-cell communication, tissue patterning, and developmental processes. Eph receptors are divided into EphA and EphB subclasses based on binding preferences for their ephrin ligands. EphA6 primarily interacts with GPI-anchored ephrin-A ligands to mediate bidirectional signaling, influencing cell adhesion, migration, and cytoskeletal dynamics. While EphA6 is less characterized compared to other Eph receptors, studies suggest its involvement in neural development, synaptic plasticity, and cancer progression, particularly in malignancies like glioblastoma and leukemia.
Antibodies targeting EphA6 are essential tools for investigating its expression, localization, and function. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to study EphA6's role in physiological and pathological contexts. Due to EphA6's potential as a therapeutic target or biomarker in diseases, specific and validated antibodies are crucial for preclinical research. Recent advances in antibody engineering have improved their specificity, enabling precise detection of EphA6 isoforms and post-translational modifications. However, challenges remain in distinguishing EphA6 from closely related Eph receptors, underscoring the need for rigorous validation in experimental models. Ongoing research continues to explore EphA6's mechanistic contributions to disease, driving demand for reliable immunological reagents.
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