| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Origin recognition complex subunit 2, ORC2, ORC2L |
| Entrez GeneID | 4999 |
| WB Predicted band size | 66.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ORC2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human ORC2L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于ORC2L抗体的参考文献(基于公开研究背景总结，非真实文献)：
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1. **文献名称**: *The Origin Recognition Complex in Human Cells: ORC2L Subunit Characterization*
**作者**: Bell, S.P., Stillman, B.
**摘要**: 该研究首次纯化并鉴定了人类细胞中ORC复合体的ORC2L亚基，开发了特异性抗体用于Western blot和免疫荧光实验，证实ORC2L在细胞核内与染色质结合，并参与DNA复制起始调控。
2. **文献名称**: *ORC2L Antibody Reveals Cell Cycle-Dependent Chromatin Binding Dynamics*
**作者**: Takeda, D.Y., et al.
**摘要**: 通过ORC2L抗体的染色质免疫沉淀(ChIP)分析，发现ORC2L在G1期特异性地结合复制起始位点，其结合水平受CDK磷酸化调控，为复制时序控制机制提供了实验证据。
3. **文献名称**: *Dysregulation of ORC2L in Cancer: Insights from Immunohistochemical Staining*
**作者**: Dellino, G.I., et al.
**摘要**: 利用ORC2L抗体对多种癌症组织进行免疫组化分析，发现ORC2L在肿瘤细胞中过表达且与基因组不稳定性相关，提示其作为潜在癌症标志物的价值。
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注：以上文献为示例性内容，实际引用时请通过PubMed或学术数据库核实真实文献信息。
The ORC2 antibody targets the ORC2 (Origin Recognition Complex subunit 2) protein, a critical component of the six-subunit Origin Recognition Complex (ORC) involved in initiating DNA replication in eukaryotic cells. ORC binds to replication origins during the G1 phase of the cell cycle, serving as a platform to recruit additional factors like Cdc6. Cdt1. and the minichromosome maintenance (MCM) complex, which together facilitate the assembly of the pre-replicative complex. ORC2. along with ORC3. ORC4. and ORC5. forms the conserved core of the ORC complex, essential for stabilizing its structure and ensuring precise replication origin licensing.
ORC2 antibodies are widely used in research to study DNA replication mechanisms, cell cycle regulation, and genome stability. They enable detection of ORC2 expression levels via techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Dysregulation of ORC2 has been linked to developmental disorders and cancers, as aberrant replication licensing can lead to genomic instability. These antibodies also help investigate ORC2's role in heterochromatin organization, transcriptional silencing, and its potential interactions with non-replication-related proteins. Validated for specificity, ORC2 antibodies are vital tools for exploring replication biology and disease mechanisms.
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