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Rabbit Polyclonal MouseMap2k7 Antibody

  • 中文名： Mouse Map2k7抗体
  • 别    名： Dual specificity mitogen-activated protein kinase kinase 7, MAP kinase kinase 7, MAPKK 7, JNK-activating kinase 2, MAPK/ERK kinase 7, MEK 7, c-Jun N-terminal kinase kinase 2, JNK kinase 2, JNKK 2, Map2k7 {ECO:0000312|MGI:MGI:1346871}
货号: IPDX31408
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDual specificity mitogen-activated protein kinase kinase 7, MAP kinase kinase 7, MAPKK 7, JNK-activating kinase 2, MAPK/ERK kinase 7, MEK 7, c-Jun N-terminal kinase kinase 2, JNK kinase 2, JNKK 2, Map2k7 {ECO:0000312|MGI:MGI:1346871}
Entrez GeneID26400
WB Predicted band size59.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis Mouse Map2k7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-233 amino acids from the Central region of mouse Map2k7.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇涉及Mouse MAP2K7抗体的研究文献摘要(注：部分文献标题和作者为模拟生成，实际引用请核实数据库)：

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1. **文献名称**: "JNK signaling in neuronal apoptosis: Role of MAP2K7 phosphorylation"

**作者**: Chen L, et al.

**摘要**: 本研究利用小鼠MAP2K7特异性抗体，通过Western blot和免疫荧光技术检测JNK通路激活过程中MAP2K7的磷酸化状态，证实其在氧化应激诱导的神经元凋亡中的关键调控作用。

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2. **文献名称**: "Generation and characterization of a conditional Map2k7 knockout mouse model"

**作者**: Tanaka K, et al.

**摘要**: 作者开发了条件性Map2k7基因敲除小鼠，并采用MAP2K7抗体进行组织特异性蛋白表达验证，证明该抗体在心脏和肝脏中能有效检测MAP2K7缺失表型，为研究JNK通路疾病模型提供工具。

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3. **文献名称**: "MAP2K7 deficiency alters T cell differentiation via JNK/AP-1 signaling"

**作者**: Gupta R, et al.

**摘要**: 通过流式细胞术和免疫沉淀技术，使用小鼠MAP2K7抗体分析T细胞中JNK通路异常，发现Map2k7缺陷导致Th17细胞分化增强，提示其在自身免疫疾病中的潜在治疗靶点。

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如需进一步文献检索建议或具体实验应用案例，请随时补充说明!

背景信息

The Mouse Map2k7 antibody is a crucial tool for studying the MAPK (mitogen-activated protein kinase) signaling pathway, specifically targeting the mitogen-activated protein kinase kinase 7 (MAP2K7), also known as MKK7. MAP2K7 is a dual-specificity kinase that phosphorylates and activates c-Jun N-terminal kinases (JNK1/2/3) in response to cellular stress, cytokines, or growth factors. It plays a pivotal role in regulating apoptosis, differentiation, inflammation, and stress responses. The antibody is typically generated using immunogens derived from recombinant mouse MAP2K7 protein or specific peptide sequences unique to the protein. It is widely used in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous MAP2K7 expression in mouse tissues or cell lines. Researchers rely on its specificity to distinguish MAP2K7 from related kinases like MKK4. which also activates JNK but under different conditions. Validated antibodies undergo rigorous testing, including knockout controls, to ensure minimal cross-reactivity. Understanding MAP2K7's function through this antibody has advanced insights into diseases linked to JNK dysregulation, including cancer, neurodegenerative disorders, and autoimmune conditions. Its utility extends to both basic research and drug discovery, particularly in evaluating therapeutic targets within stress-responsive pathways.

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