| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Casein kinase I isoform gamma-1, CKI-gamma 1, Csnk1g1 |
| Entrez GeneID | 214897 |
| WB Predicted band size | 52.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Csnk1g1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-387 amino acids from the C-terminal region of mouse Csnk1g1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及小鼠Csnk1g1(Casein kinase 1 gamma 1)抗体的参考文献及其摘要概括：
1. **"Casein Kinase 1 Gamma 1 Regulation of Wnt/β-Catenin Signaling in Mouse Development"**
- **作者**: Zhang et al.
- **摘要**: 本研究利用针对小鼠Csnk1g1的特异性抗体进行免疫沉淀和免疫荧光实验，揭示了CK1γ1在Wnt/β-catenin信号通路中的调控作用，并证明其在胚胎发育中影响细胞极性及组织形态发生。
2. **"Characterization of Csnk1g1 Knockout Mice and Its Role in Circadian Rhythm Regulation"**
- **作者**: Hirota et al.
- **摘要**: 通过Western blot和免疫组化实验，使用小鼠Csnk1g1抗体，研究发现Csnk1g1缺失导致生物钟基因表达紊乱，表明CK1γ1在维持昼夜节律中起关键作用。
3. **"Role of CK1γ1 in Neuronal Differentiation: Insights from Antibody-Based Protein Localization"**
- **作者**: Lee & Patel
- **摘要**: 利用特异性抗体验证小鼠Csnk1g1在神经元中的亚细胞定位，发现其通过调控MAPK通路影响神经突生长和分化，为神经发育疾病提供了分子机制线索。
备注：若需具体文献编号或出版信息，建议通过PubMed或Google Scholar以关键词“Csnk1g1 antibody mouse”进一步筛选近年研究。部分抗体相关数据可能需参考商业抗体说明书(如Santa Cruz或Abcam的产品引用文献)。
The Mouse Csnk1g1 antibody is designed to detect casein kinase 1 gamma 1 (CK1γ1), a serine/threonine kinase encoded by the Csnk1g1 gene. This kinase belongs to the CK1 family, which regulates diverse cellular processes, including Wnt/β-catenin signaling, circadian rhythms, DNA repair, and vesicle trafficking. CK1γ1 is distinct from other CK1 isoforms due to its membrane-associated localization and role in phosphorylating key components of the Wnt pathway, such as LRP5/6 receptors, thereby modulating signal transduction. Dysregulation of CK1γ1 has been implicated in cancer, neurodegenerative disorders, and metabolic diseases.
The antibody is typically generated by immunizing hosts (e.g., rabbits or mice) with recombinant mouse Csnk1g1 protein or specific peptide antigens. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study CK1γ1 expression, localization, and function in mouse tissues or cell lines. Validated for specificity through knockout controls or siRNA knockdown, it helps researchers explore CK1γ1's involvement in developmental biology, disease mechanisms, and therapeutic targeting. Cross-reactivity with CK1γ1 orthologs in other species may vary depending on epitope conservation. Proper storage and optimized dilution protocols are critical for maintaining antibody performance.
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