| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43 |
| Entrez GeneID | 6693 |
| WB Predicted band size | 40.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SPN/CD43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-60 amino acids from the N-terminal region of human SPN/CD43. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SPN/CD43 (N-term)抗体的3篇模拟参考文献(内容为虚构，仅供参考)：
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1. **文献名称**：*Targeting the N-terminal Epitope of CD43 in Acute Lymphoblastic Leukemia*
**作者**：Smith A, et al.
**摘要**：研究利用针对CD43 N端结构域的单克隆抗体，通过流式细胞术和免疫印迹分析，揭示了CD43在白血病细胞表面的异常高表达及其与预后的相关性。
2. **文献名称**：*A Novel Anti-SPN Antibody Reveals Its Role in T-cell Activation*
**作者**：Jones B, et al.
**摘要**：开发并验证了一种特异性识别SPN蛋白N端的新型抗体，证实其在T细胞活化过程中通过调控细胞膜表面黏附分子的分布影响免疫突触形成。
3. **文献名称**：*CD43 N-terminal Antibody in Inflammatory Disease Models*
**作者**：Lee C, et al.
**摘要**：采用N端特异性抗CD43抗体进行免疫组化分析，发现CD43在炎症组织中白细胞的迁移和黏附中起关键作用，为治疗自身免疫疾病提供新靶点。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词(如“CD43 N-terminal antibody”或“SPN antibody application”)，并筛选涉及抗体开发、机制研究或疾病模型的论文。
The SPN/CD43 (N-term) antibody targets the N-terminal region of sialophorin (SPN), also known as CD43. a cell surface glycoprotein prominently expressed on leukocytes, including T cells, neutrophils, and thymocytes. CD43 is characterized by its extended extracellular domain, rich in O-linked glycosylation, which contributes to its anti-adhesive properties and immune regulatory functions. This glycoprotein plays roles in T-cell activation, apoptosis, and leukocyte migration, while also serving as a receptor for pathogens like HIV-1.
The SPN/CD43 (N-term) antibody is widely used in immunological research to study CD43 expression, localization, and function in health and disease. It is applied in techniques such as flow cytometry, Western blotting, and immunohistochemistry to investigate CD43's involvement in immune responses, inflammatory disorders, and malignancies. Aberrant CD43 expression has been linked to leukemia, autoimmune diseases, and immunodeficiency syndromes, making this antibody a valuable tool for both basic research and clinical diagnostics. Its specificity for the N-terminal region ensures recognition of the native protein while avoiding cross-reactivity with other glycoproteins sharing similar glycosylation patterns.
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