| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5 |
| Entrez GeneID | 166 |
| WB Predicted band size | 22.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This AES antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the C-terminal region of human AES. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AES(Advanced Encryption Standard)抗体的模拟参考文献示例(注：AES抗体在学术文献中并非常见术语，可能与具体研究领域相关，以下为假设性示例)：
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1. **文献名称**: *Autoantibodies against AES protein in autoimmune encephalitis: Clinical relevance and diagnostic potential*
**作者**: Smith J, et al.
**摘要**: 研究探讨了AES(氨基酸末端增强子剪切变体)蛋白自身抗体在自身免疫性脑炎患者中的表达及其临床意义。通过ELISA和Western blot分析，发现AES抗体与特定神经症状相关，可能作为新型生物标志物用于诊断亚型分类。
2. **文献名称**: *AES-1 antibody as a novel therapeutic target in colorectal cancer*
**作者**: Lee H, et al.
**摘要**: 研究验证了AES-1抗体在结直肠癌细胞系中的抗肿瘤活性。实验表明，靶向AES蛋白的单克隆抗体可抑制肿瘤细胞增殖并诱导凋亡，提示其在癌症免疫治疗中的潜在应用。
3. **文献名称**: *Characterization of AES autoantibodies in systemic lupus erythematosus*
**作者**: Garcia R, et al.
**摘要**: 分析了系统性红斑狼疮(SLE)患者血清中AES抗体的频率及其与疾病活动的关联。结果显示，AES抗体阳性患者更易出现肾脏受累，提示其可能参与SLE的病理机制。
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**注意**：若需真实文献，建议通过PubMed、Google Scholar等平台检索"AES antibody"或结合具体研究背景(如AES蛋白功能、相关疾病等)优化关键词。
**Background of AES Antibodies**
AES (Amino-terminal Enhancer of Split), also known as GRG5. is a member of the Groucho/Transducin-like Enhancer of Split (TLE) family, functioning as a transcriptional corepressor. It lacks the C-terminal WD40 domain present in other TLE proteins, which limits its ability to directly bind DNA but allows it to modulate transcriptional repression through interactions with other regulatory proteins, such as histone deacetylases (HDACs) or β-catenin. AES plays critical roles in developmental processes and cellular homeostasis by regulating Notch, Wnt, and other signaling pathways involved in differentiation, proliferation, and apoptosis.
AES antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to explore AES's role in diseases, particularly cancer. For instance, AES has been implicated as both a tumor suppressor and promoter in different contexts, with studies linking its altered expression to prostate, breast, and colorectal cancers. However, challenges remain in characterizing AES-specific functions due to overlapping roles with other TLE members and context-dependent signaling effects. Researchers often validate antibody specificity using knockout controls to ensure accurate detection in complex biological systems.
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