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Rabbit Polyclonal PITRM1 Antibody

  • 中文名： PITRM1抗体
  • 别    名： Presequence protease, mitochondrial, hPreP, 3424-, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1, PITRM1, KIAA1104, MP1
货号: IPDX31078
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesPresequence protease, mitochondrial, hPreP, 3424-, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1, PITRM1, KIAA1104, MP1
Entrez GeneID10531
WB Predicted band size117.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the Central region of human PITRM1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇与PITRM1抗体相关的参考文献(示例为模拟文献结构，具体内容需根据实际研究补充)：

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1. **文献名称**：*Mitochondrial protease PITRM1 degradation of amyloid-β in Alzheimer's disease models*

**作者**：Brunetti D, et al.

**摘要**：研究利用PITRM1抗体，通过Western blot和免疫荧光技术，证明PITRM1在线粒体中降解Aβ多肽的功能缺失与阿尔茨海默病神经元损伤相关，敲除小鼠模型中PITRM1表达导致淀粉样蛋白积累。

2. **文献名称**：*PITRM1 deficiency induces mitochondrial fragmentation and oxidative stress*

**作者**：Garcia-Venzor A, et al.

**摘要**：通过PITRM1抗体检测细胞线粒体裂变蛋白表达变化，发现PITRM1缺失导致线粒体动态失衡和ROS水平升高，提示其在维持线粒体稳态中的关键作用。

3. **文献名称**：*Structural insights into PITRM1 protease activity using cryo-EM*

**作者**：Li Y, et al.

**摘要**：结合PITRM1特异性抗体进行免疫共沉淀，解析了PITRM1与底物结合的冷冻电镜结构，揭示其底物识别机制及与神经退行性疾病的潜在关联。

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注：以上文献信息为示例性内容，实际引用需核实具体研究。建议通过 **PubMed** 或 **Web of Science** 以关键词"PITRM1 antibody"+"protease"+"mitochondria"检索最新文献。

背景信息

The PITRM1 (Pitrilysin Metallopeptidase 1) antibody is a tool used to study the PITRM1 protein, a mitochondrial metallopeptidase critical for protein quality control. PITRM1. also known as PreP or MP1. localizes to the mitochondrial matrix and degrades misfolded or damaged peptides, including amyloid-β (Aβ) fragments, through its zinc-dependent enzymatic activity. Discovered for its role in Aβ clearance, PITRM1 has been linked to neurodegenerative disorders like Alzheimer’s disease, as its dysfunction may contribute to Aβ accumulation in mitochondria. Studies in human cell models and mice lacking PITRM1 reveal impaired mitochondrial function, oxidative stress, and neurodegeneration. The antibody, typically raised in rabbits or mice, detects PITRM1 in applications such as Western blot, immunofluorescence, and immunohistochemistry. It aids in elucidating PITRM1’s expression patterns, interactions, and regulatory mechanisms. Recent research highlights its involvement in processing mitochondrial precursor proteins and maintaining proteostasis, making it a potential therapeutic target. Validation of PITRM1 antibodies includes specificity tests using knockout cell lines or tissues. Ongoing studies explore its broader roles in aging, metabolic diseases, and neuroprotection, emphasizing its importance in mitochondrial biology and disease pathology.

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