| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Translin, 31--, Component 3 of promoter of RISC, C3PO, TSN |
| Entrez GeneID | 7247 |
| WB Predicted band size | 26.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This TSN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human TSN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TSN抗体的3篇参考文献的简要概括(文献名称与作者为虚构示例，仅供格式参考)：
1. **《Tudor-SN蛋白在结肠癌中的表达及临床意义》- 作者：李明等**
摘要：研究通过TSN抗体检测发现，Tudor-SN蛋白在结肠癌组织中高表达，与肿瘤转移和患者预后不良显著相关，提示其可能作为潜在治疗靶点。
2. **《TSN抗体在小鼠神经炎症模型中的应用》- 作者：Smith J et al.**
摘要：利用TSN特异性抗体阻断Tudor-SN功能，发现其可减轻小鼠中枢神经炎症反应，表明Tudor-SN在调控炎症信号通路中起关键作用。
3. **《Tudor-SN与RNA代谢的分子机制研究》- 作者：Chen R et al.**
摘要：通过免疫沉淀(IP)结合TSN抗体，揭示Tudor-SN蛋白通过与特定mRNA结合调控细胞应激颗粒形成，影响细胞应激应答和存活机制。
注：以上文献信息为模拟内容，实际研究中请通过PubMed或Google Scholar等平台检索真实发表的论文。
**Background of TSN Antibody**
TSN (Translin) antibodies are immunological tools designed to detect and study Translin, a highly conserved DNA- and RNA-binding protein involved in diverse cellular processes. Translin, encoded by the *TSN* gene, was initially identified for its role in chromosomal translocations in lymphoid cancers. It forms a complex with its partner TRAX (Translin-associated factor X), creating the Translin-TRAX complex (C3PO), which exhibits endoribonuclease activity critical for processing small RNAs, including microRNAs and small interfering RNAs (siRNAs). This complex regulates RNA interference pathways, mRNA transport, and translation, impacting gene expression and genome stability.
TSN is implicated in neurodevelopment, gametogenesis, and DNA repair. Aberrant TSN expression or function has been linked to neurological disorders, infertility, and cancer. For instance, TSN deficiency disrupts spermatogenesis and oogenesis, while its overexpression in tumors may influence cell proliferation and metastasis.
TSN antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TSN's expression, localization, and interactions in biological samples. They enable researchers to explore TSN's role in RNA metabolism, its response to cellular stress, and its potential as a therapeutic target. Recent studies also highlight TSN's involvement in extracellular vesicle-mediated RNA transfer, expanding its relevance in cell-cell communication and disease mechanisms.
In summary, TSN antibodies are vital for elucidating the multifaceted roles of Translin in health and disease, bridging molecular biology with clinical research.
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