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Rabbit Polyclonal ZNF417 Antibody

  • 中文名: ZNF417抗体
  • 别    名: Zinc finger protein 417, ZNF417
货号: IPDX31071
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesZinc finger protein 417, ZNF417
Entrez GeneID147687
WB Predicted band size65.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ZNF417 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the Central region of human ZNF417.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ZNF417抗体的3篇文献示例(注:以下内容为模拟虚构,实际文献需通过学术数据库检索验证):

1. **文献名称**:*ZNF417 regulates neuronal differentiation through epigenetic modulation of target genes*

**作者**:Chen L, et al.

**摘要**:本研究利用ZNF417特异性抗体,通过ChIP-seq技术揭示了ZNF417在神经干细胞分化过程中通过结合特定基因启动子区域调控组蛋白修饰的机制,表明其在神经发育中的关键作用。

2. **文献名称**:*Development and validation of a high-affinity monoclonal antibody for ZNF417 protein detection*

**作者**:Wang Y, et al.

**摘要**:报道了一种新型ZNF417单克隆抗体的制备与验证,通过Western blot和免疫荧光证实其特异性,并应用于癌症组织样本分析,发现ZNF417在结直肠癌中表达异常。

3. **文献名称**:*ZNF417 interacts with p53 to suppress tumorigenesis in hepatocellular carcinoma*

**作者**:Zhang R, et al.

**摘要**:通过免疫共沉淀(使用ZNF417抗体)和功能实验,证明ZNF417与p53蛋白直接互作,增强p53的转录活性,从而抑制肝癌细胞增殖,为ZNF417的抑癌功能提供证据。

如需真实文献,建议在PubMed或Web of Science中以“ZNF417 antibody”或“ZNF417 function”为关键词检索。

背景信息

The ZNF417 antibody is a research tool designed to detect and study the zinc finger protein 417 (ZNF417), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZNF) family. ZNF417 is part of a large group of transcription factors characterized by tandem C2H2-type zinc finger motifs, which mediate sequence-specific DNA binding, and a KRAB domain that often recruits transcriptional repressor complexes. These proteins play roles in gene regulation, chromatin remodeling, and cellular processes such as differentiation and development. ZNF417. located on human chromosome 19. is implicated in transcriptional repression through interactions with chromatin-modifying enzymes. However, its precise biological functions and target genes remain under investigation. Antibodies against ZNF417 are typically developed in model organisms (e.g., rabbits or mice) using immunogenic peptide sequences or recombinant protein fragments. They enable researchers to analyze ZNF417 expression, localization, and protein-protein interactions via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes knockout/knockdown controls to confirm specificity. Studying ZNF417 may shed light on its role in diseases, particularly cancers or neurological disorders, where zinc finger proteins are increasingly linked to pathological mechanisms.

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