| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Putative neuroblastoma breakpoint family member 5, NBPF5P, NBPF5 |
| WB Predicted band size | 40.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NBPF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-291 amino acids from the C-terminal region of human NBPF5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NBPF5抗体的模拟参考文献示例(注：以下内容为虚构，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: "NBPF5 Antibody Characterization in Neuroblastoma Cell Lines"
**作者**: Smith J, et al.
**摘要**: 本研究通过免疫印迹和免疫组化验证了一种新型NBPF5抗体的特异性，发现其在神经母细胞瘤细胞系中高表达，并与MYCN扩增呈负相关，提示NBPF5可能作为神经母细胞瘤分型的潜在标志物。
2. **文献名称**: "Functional Analysis of NBPF5 in Genomic Instability Using Specific Antibodies"
**作者**: Lee S, et al.
**摘要**: 利用NBPF5抗体探究其在维持基因组稳定性中的作用，发现NBPF5蛋白通过与染色质重塑复合物相互作用，减少DNA损伤积累，可能参与癌症发生中的染色体结构调控。
3. **文献名称**: "NBPF5 Expression in Human Brain Development: Antibody Validation and Spatial Localization"
**作者**: Garcia R, et al.
**摘要**: 通过验证NBPF5抗体的交叉反应性，揭示了该蛋白在胎儿大脑皮层发育过程中的动态表达模式，提示其在神经前体细胞分化和迁移中的潜在功能。
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如需真实文献，建议通过PubMed或Google Scholar以关键词“NBPF5 antibody”或“NBPF5 protein function”检索，并筛选涉及抗体应用的研究。
The NBPF5 (Neuroblastoma Breakpoint Family Member 5) antibody is a tool used to study the NBPF gene family, which is unique to primates and implicated in brain development and evolution. NBPF genes encode proteins containing conserved DUF1220 domains, linked to cortical neuron proliferation and human-specific neuroanatomical features. NBPF5. located on chromosome 1q21.1. has garnered attention due to its association with neurodevelopmental disorders and cancer. Deletions or duplications in this genomic region are linked to microcephaly, autism, schizophrenia, and neuroblastoma.
The NBPF5 antibody specifically detects the NBPF5 protein, enabling researchers to investigate its expression patterns, subcellular localization, and functional roles. Studies suggest NBPF5 may act as a tumor suppressor in certain cancers, with reduced expression observed in aggressive malignancies. In neuroscience, it serves as a marker to explore DUF1220 domain functions in neural progenitor differentiation and brain size regulation. This antibody is typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, supporting research into both developmental biology and disease mechanisms. Its utility extends to comparative studies of primate-specific genomic innovations and their contributions to human health and disease.
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