| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leucine-rich repeat-containing protein 52, BK channel auxiliary gamma subunit LRRC52, LRRC52 |
| Entrez GeneID | 440699 |
| WB Predicted band size | 35.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LRRC52 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the C-terminal region of human LRRC52. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LRRC52抗体的3篇示例参考文献(注：以下内容为模拟虚构，实际引用时请核实文献真实性)：
1. **标题**：LRRC52 regulates sperm motility via calcium channel modulation in murine models
**作者**：Smith A, et al.
**摘要**：本研究利用LRRC52特异性抗体，发现LRRC52与精子鞭毛中的CatSper钙通道复合物相互作用，调控精子运动能力。抗体阻断实验表明LRRC52缺失导致精子活力显著下降。
2. **标题**：LRRC52 antibody reveals its expression in cochlear hair cells and auditory dysfunction
**作者**：Chen L, et al.
**摘要**：通过免疫组化结合LRRC52抗体，发现LRRC52在小鼠耳蜗毛细胞中高表达。基因敲除模型显示LRRC52缺失导致听觉信号传导异常，提示其在听觉功能中的关键作用。
3. **标题**：Development of a monoclonal antibody against LRRC52 for cancer biomarker screening
**作者**：Tanaka K, et al.
**摘要**：研究团队开发了高特异性的LRRC52单克隆抗体，并验证其在多种肿瘤组织中的表达差异，提示LRRC52可能作为癌症诊断或预后的潜在生物标志物。
4. **标题**：LRRC52 interacts with TMC1 in mechanoelectrical transduction: Evidence from antibody-based co-immunoprecipitation
**作者**：Wang Y, et al.
**摘要**：利用LRRC52抗体进行免疫共沉淀实验，证实LRRC52与听觉机械转导通道蛋白TMC1存在直接相互作用，为阐明听觉分子机制提供了新证据。
**注意**：以上文献为示例，实际研究中请通过PubMed或Web of Science等平台检索真实文献。
**Background of LRRC52 Antibody**
LRRC52 (Leucine-Rich Repeat-Containing Protein 52) is a member of the leucine-rich repeat (LRR) protein family, characterized by repetitive structural motifs involved in protein-protein interactions. It is primarily expressed in specialized cell types, including sperm cells and ciliated tissues. Studies suggest LRRC52 functions as an auxiliary subunit of ion channels, particularly the CatSper (cation channel of sperm) complex, which is critical for sperm motility and male fertility. It may regulate channel activity, calcium signaling, or structural stability.
LRRC52 has also been linked to ciliary function in respiratory and reproductive systems. Its dysregulation is implicated in conditions like asthenozoospermia (reduced sperm motility) and primary ciliary dyskinesia. Antibodies targeting LRRC52 are essential tools for investigating its expression, localization, and interaction partners in physiological and pathological contexts. They enable Western blotting, immunohistochemistry, and functional studies to elucidate its role in fertility, ion channel regulation, and cilia-associated disorders. Commercial LRRC52 antibodies are typically validated for specificity in human or model organisms, aiding research in reproductive biology and ciliopathies.
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