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Rabbit Polyclonal LHFPL5 Antibody

  • 中文名： LHFPL5抗体
  • 别    名： Tetraspan membrane protein of hair cell stereocilia, Lipoma HMGIC fusion partner-like 5 protein, LHFPL5, TMHS
货号: IPDX30767
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTetraspan membrane protein of hair cell stereocilia, Lipoma HMGIC fusion partner-like 5 protein, LHFPL5, TMHS
Entrez GeneID222662
WB Predicted band size24.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis LHFPL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-214 amino acids from the C-terminal region of human LHFPL5.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于LHFPL5抗体的模拟参考文献示例(注：内容为学术场景模拟，建议通过PubMed或Google Scholar验证真实文献)：

1. **文献名称**：LHFPL5抗体在内耳毛细胞中的特异性定位及功能研究

**作者**：Zhang, Y. et al.

**摘要**：本研究利用LHFPL5特异性抗体，揭示了该蛋白在耳蜗毛细胞静纤毛基部的表达模式，证实其参与机械转导通道的组装，突变导致小鼠听力丧失。

2. **文献名称**：基于LHFPL5抗体的遗传性耳聋分子诊断新方法

**作者**：Chen, L. et al.

**摘要**：开发了一种高灵敏度LHFPL5抗体检测技术，用于筛查人类耳聋患者中LHFPL5基因突变，为早期诊断提供可靠工具。

3. **文献名称**：LHFPL5与TMC1的相互作用研究：抗体介导的共免疫沉淀分析

**作者**：Wang, X. et al.

**摘要**：通过LHFPL5抗体进行共免疫沉淀实验，发现其与跨膜通道蛋白TMC1直接互作，阐明二者在听觉信号传递中的协同机制。

4. **文献名称**：LHFPL5抗体在蛋白质印迹中的优化及应用

**作者**：Kim, S. et al.

**摘要**：系统评估了不同LHFPL5抗体的特异性与效价，优化Western Blot条件，为内耳组织蛋白表达定量提供标准化方案。

(提示：实际文献需结合具体研究目标筛选，例如侧重基础机制、疾病模型或临床转化方向。)

背景信息

LHFPL5 (Lipoma HMGIC Fusion Partner-Like 5) antibody is a tool used to study the LHFPL5 protein, which belongs to the LHFPL tetraspan transmembrane protein family. Initially identified through its homology to the HMGIC fusion partner in lipomas, LHFPL5 is highly expressed in the inner ear, particularly in hair cells of the cochlea and vestibule. It plays a critical role in auditory function by contributing to the organization and stability of stereocilia bundles, essential for mechanotransduction in hearing. Mutations in the LHFPL5 gene are linked to autosomal recessive non-syndromic hearing loss (DFNB67), highlighting its importance in maintaining normal hearing. Research using LHFPL5 antibodies has focused on elucidating its localization, interaction partners (e.g., TMC1. TMIE), and mechanisms underlying hair cell dysfunction in hearing impairment models. These antibodies are commonly applied in immunohistochemistry, Western blotting, and immunofluorescence to visualize protein expression patterns in tissues, particularly in murine models. Studies suggest LHFPL5 may anchor mechanotransduction channels or regulate their assembly, though its precise molecular role remains under investigation. The antibody serves as a key reagent in both basic research and potential diagnostic applications for genetic hearing disorders.

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