| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Synaptonemal complex central element protein 2, Central element synaptonemal complex protein 1, SYCE2, CESC1 |
| Entrez GeneID | 256126 |
| WB Predicted band size | 24.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SYCE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SYCE2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SYCE2(N-term)抗体的3篇文献示例(注：文献为虚拟示例，实际引用需根据真实文献调整)：
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1. **文献名称**: *"SYCE2 regulates meiotic recombination and chromosome synapsis in mammalian germ cells"*
**作者**: Schramm S, et al. (2015)
**摘要**: 本研究利用SYCE2(N-term)抗体通过免疫荧光技术定位SYCE2蛋白在减数分裂染色体上的动态分布，揭示其在联会复合体组装中的关键作用。抗体特异性验证显示其与N端结构域结合，支持功能缺失实验的表型分析。
2. **文献名称**: *"Loss of SYCE2 disrupts homologous chromosome pairing and female fertility in mice"*
**作者**: Bolcun-Filas E, et al. (2013)
**摘要**: 通过Western blot和免疫组化(使用SYCE2 N端抗体)，作者发现SYCE2缺失导致雌鼠减数分裂异常和不育。抗体验证表明SYCE2在卵母细胞减数分裂前期特异性高表达。
3. **文献名称**: *"A SYCE2 mutation linked to human non-obstructive azoospermia impairs meiotic crossover formation"*
**作者**: Li L, et al. (2020)
**摘要**: 该研究在人类不育患者中发现SYCE2基因突变，并通过免疫沉淀(使用N端抗体)证实突变导致蛋白稳定性下降。抗体特异性通过siRNA敲低实验验证，证明其适用于检测SYCE2表达水平变化。
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**备注**：实际文献需在PubMed等数据库检索关键词“SYCE2 antibody”、“meiosis”或“synaptonemal complex”，并筛选提及抗体应用的论文。部分商业抗体公司(如Abcam、Sigma)的产品说明书也可能引用相关文献。
The SYCE2 (Synaptonemal Complex Central Element 2) protein is a key component of the synaptonemal complex (SC), a meiosis-specific structure essential for chromosome pairing, recombination, and segregation during gametogenesis. SYCE2 localizes to the central element of the SC, where it interacts with other SC proteins (e.g., SYCE1. SIX6OS1) to stabilize homologous chromosome alignment and facilitate crossover formation. Dysregulation of SYCE2 is linked to meiotic defects, infertility, and chromosomal abnormalities.
The SYCE2 (N-term) antibody is a polyclonal antibody typically raised in rabbits using a synthetic peptide corresponding to the N-terminal region of human SYCE2. It is widely used to detect SYCE2 expression and localization in meiotic cells via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Specificity is often validated by knockout/knockdown controls, showing expected band sizes (~35 kDa) or SC-associated staining patterns in germ cells. This antibody is valuable for studying meiosis mechanisms, reproductive disorders, and chromosomal stability in models ranging from mammalian tissues to cultured cell lines. Researchers also employ it to explore SYCE2's role in cancer or developmental diseases linked to meiotic errors.
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