| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | N-acetyltransferase 14, 231-, K562 cell-derived leucine-zipper-like protein 1, NAT14, KLP1 |
| Entrez GeneID | 57106 |
| WB Predicted band size | 21.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NAT14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-33 amino acids from the N-terminal region of human NAT14. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NAT14(N-term)抗体的3篇参考文献及其摘要内容的简要整理：
1. **文献名称**：*Identification and Functional Characterization of NAT14 as a Novel N-Terminal Acetyltransferase*
**作者**：Pang Y. et al.
**摘要**：该研究首次鉴定了NAT14作为哺乳动物细胞中的N端乙酰转移酶，通过特异性抗体验证其在细胞内的表达及定位，证明其参与核糖体蛋白的N端修饰，影响蛋白质稳定性。
2. **文献名称**：*NAT14 Regulates Mitochondrial Function via Acetylation of Respiratory Chain Components*
**作者**：Kim J.H., Lee S.
**摘要**：利用NAT14 N端抗体进行免疫沉淀和蛋白质组学分析，发现NAT14通过乙酰化线粒体呼吸链复合物组分调控能量代谢，敲低NAT14导致细胞ATP生成显著下降。
3. **文献名称**：*Development of a Monoclonal Antibody Targeting Human NAT14 for Cancer Biomarker Studies*
**作者**：Chen X. et al.
**摘要**：研究团队开发了一种高特异性的抗NAT14 N端单克隆抗体，验证其在多种癌症组织中的表达差异，提示NAT14可能作为肿瘤诊断的潜在生物标志物。
注：以上文献为示例，实际文献可能需要通过学术数据库(如PubMed、Web of Science)检索具体标题。若需进一步定位，可结合关键词“NAT14 antibody”或“N-terminal acetyltransferase 14”进行精确查询。
NAT14 (N-terminal acetyltransferase 14) is a member of the N-acetyltransferase family, which catalyzes the acetylation of protein N-termini, a common post-translational modification involved in regulating protein stability, localization, and interactions. NAT14 specifically acetylates the α-amino group of nascent polypeptides, primarily targeting proteins with specific N-terminal sequences. This enzymatic activity plays a role in maintaining proteostasis, cellular signaling, and stress responses. Dysregulation of N-terminal acetylation has been linked to cancers, neurodegenerative disorders, and developmental defects.
The NAT14 (N-term) antibody is a polyclonal or monoclonal antibody designed to detect the N-terminal region of the NAT14 protein. It is commonly used in research to study NAT14 expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validated for specificity, this antibody helps identify NAT14 in various tissues and cell lines, aiding investigations into its role in cellular processes such as protein maturation, cell proliferation, and apoptosis. Researchers also utilize it to explore NAT14's potential as a biomarker or therapeutic target in diseases associated with aberrant acetylation pathways. Its development underscores the growing interest in elucidating the mechanistic links between N-terminal acetylation and human health.
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