| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | von Willebrand factor A domain-containing protein 3B, VWA3B |
| Entrez GeneID | 200403 |
| WB Predicted band size | 145.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This VWA3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1178-1207 amino acids from the C-terminal region of human VWA3B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于VWA3B抗体的示例性参考文献(注：由于VWA3B研究较为小众，以下内容为模拟示例，实际文献需通过学术数据库验证)：
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1. **文献名称**: *VWA3B as a Novel Biomarker in Colorectal Cancer: Expression Analysis Using a Specific Polyclonal Antibody*
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种针对VWA3B蛋白的多克隆抗体，并验证其在结直肠癌组织中的高表达。免疫组化结果显示，VWA3B表达与肿瘤侵袭性显著相关，提示其潜在临床价值。
2. **文献名称**: *Functional Characterization of VWA3B in Neuronal Development via CRISPR and Antibody-Based Knockdown*
**作者**: Lee H, et al.
**摘要**: 通过CRISPR技术结合VWA3B抗体的功能阻断实验，发现VWA3B在小鼠神经元突触形成中起关键作用，抗体应用证实其参与Wnt信号通路调控。
3. **文献名称**: *Structural Insights into VWA3B Domain Interactions Using Epitope-Specific Monoclonal Antibodies*
**作者**: Garcia R, et al.
**摘要**: 报道了针对VWA3B结构域的单克隆抗体制备，并通过X射线晶体学揭示了VWA3B与整合素β亚基的结合模式，抗体阻断实验支持其作为治疗靶点的潜力。
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**建议**：实际研究中，VWA3B相关文献可能较少，建议通过PubMed或Google Scholar以“VWA3B antibody”、“VWA3B function”等关键词检索，或关注其同源蛋白(如VWA1、VWA2)的研究。部分抗体公司(如Abcam、Santa Cruz)的产品说明书也可能提供应用参考文献。
The VWA3B (Von Willebrand Factor A Domain Containing 3B) antibody is a tool used to study the VWA3B protein, a member of the von Willebrand factor A (vWA) domain-containing protein family. This protein is implicated in extracellular matrix interactions, cell adhesion, and intracellular signaling due to the conserved vWA domain, which often mediates protein-protein interactions. VWA3B is expressed in various tissues, including the brain, kidney, and reproductive organs, though its precise biological functions remain under investigation.
Research suggests VWA3B may play roles in cancer progression and neurological disorders. For instance, altered VWA3B expression has been observed in gliomas and prostate cancer, potentially influencing tumor invasiveness or therapeutic resistance. Antibodies targeting VWA3B enable the detection of its expression patterns, post-translational modifications, and interactions in disease models. These antibodies are typically developed in hosts like rabbits or mice using immunogenic peptide sequences specific to VWA3B.
Despite progress, challenges persist in characterizing VWA3B's exact mechanisms and validating antibody specificity across experimental conditions. Current studies focus on clarifying its role in cellular pathways and exploring its potential as a diagnostic or therapeutic biomarker. The VWA3B antibody thus serves as a critical reagent for advancing understanding of this understudied protein in both physiological and pathological contexts.
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