| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ubiquitin-like protein FUBI, FAU |
| Entrez GeneID | 2197 |
| WB Predicted band size | 7.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FAU antibody is generated from rabbits immunized with human FAU recombinant protein. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FAU抗体的模拟参考文献示例(文献为虚构，仅供格式参考)：
1. **文献名称**: *FAU Antibody Application in Detecting Tumor Suppressor Activity in Breast Cancer*
**作者**: Smith J, Lee R, Garcia M
**摘要**: 本研究利用FAU特异性抗体分析乳腺癌组织中的蛋白表达水平，发现FAU低表达与肿瘤恶性程度及患者生存率下降显著相关。Western blot和免疫荧光结果显示FAU通过调控p53通路抑制肿瘤生长。
2. **文献名称**: *FAU as a Novel Biomarker in Colorectal Cancer: Validation by Immunohistochemistry*
**作者**: Chen L, Wang H, Kimura T
**摘要**: 通过免疫组化技术，作者证实FAU抗体在结直肠癌组织中特异性高表达，且与化疗耐药性呈负相关。研究提示FAU可能作为预后标志物及潜在治疗靶点。
3. **文献名称**: *Functional Characterization of FAU Antibody in Apoptosis Regulation*
**作者**: Müller S, Fischer D, Alvarez R
**摘要**: 该研究通过基因沉默和FAU抗体验证，发现FAU蛋白通过抑制Bcl-2家族蛋白促进凋亡。实验表明，FAU表达缺失导致癌细胞凋亡率降低，提示其在凋亡通路中的关键作用。
4. **文献名称**: *FAU Antibody Cross-Reactivity Analysis in Murine Models*
**作者**: Patel K, O'Connor T, Zhang Y
**摘要**: 本文评估了FAU抗体在小鼠模型中的交叉反应性，确认其对不同组织来源样本的特异性。研究发现FAU在正常组织中广泛表达，但在肝癌中显著下调，支持其肿瘤抑制功能。
**注**：以上文献为模拟示例，非真实存在。实际研究中建议通过学术数据库(如PubMed)检索最新文献。
The FAU antibody targets the FAU protein, encoded by the FAU gene (Finkel-Biskis-Reilly murine sarcoma virus [FBR-MuSV] ubiquitously expressed gene). Discovered in the context of oncogenic retrovirus studies, FAU is evolutionarily conserved and ubiquitously expressed across tissues. It encodes a fusion protein (FUB1) containing a ubiquitin-like domain (FUBI) at its N-terminus and the ribosomal protein S30 (RPS30) at the C-terminus. FAU plays dual roles in cellular regulation: it is implicated in apoptosis through interactions with p53 and Bcl-2 family proteins, and it participates in ribosome biogenesis via RPS30.
FAU antibodies are critical tools for studying its expression, localization, and function in physiological and pathological contexts. Research has linked FAU dysregulation to cancer progression, as altered FAU expression affects apoptosis, cell proliferation, and stress responses. For example, FAU downregulation is observed in certain malignancies, suggesting tumor-suppressive potential. Antibodies against FAU enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding investigations into its role in diseases, including neurodegenerative disorders and metabolic syndromes.
Despite its established roles, FAU's mechanisms remain partially elusive, driving ongoing research. FAU antibodies thus serve as essential reagents for unraveling its complex biological networks and therapeutic potential.
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