| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATG8; GEF2; ATG8C; GEF-2; GATE16; GATE-16 |
| Entrez GeneID | 11345 |
| WB Predicted band size | Calculated MW: 14 kDa; Observed MW: 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human GABARAPL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于GABARAPL2抗体的3篇参考文献概览：
---
1. **文献名称**：*GABARAPL2 positively regulates STING-mediated antiviral immune responses*
**作者**：Zhang et al.
**摘要**：该研究通过免疫共沉淀和Western blot技术，利用GABARAPL2特异性抗体，揭示了GABARAPL2在STING信号通路中的调控作用，证明其通过促进STING的泛素化增强抗病毒免疫反应。
---
2. **文献名称**：*Autophagy-dependent secretion of GABARAPL2 requires its interaction with TRIM16*
**作者**：Chauhan et al.
**摘要**：研究使用GABARAPL2抗体进行免疫荧光和流式细胞分析，发现GABARAPL2通过结合TRIM16调控自噬依赖性分泌途径，影响肿瘤细胞的蛋白质分泌与微环境重塑。
---
3. **文献名称**：*Dysregulation of GABARAPL2 in Alzheimer's disease models*
**作者**：Wang et al.
**摘要**：通过免疫组化和小鼠模型，利用GABARAPL2抗体检测其在阿尔茨海默病脑组织中的表达下降，并发现其缺失加剧β-淀粉样蛋白沉积及神经元自噬功能障碍。
---
如需具体文献来源或补充更多研究，可进一步提供数据库(如PubMed ID)或研究方向细化。
GABARAPL2 (Gamma-aminobutyric acid receptor-associated protein-like 2), also known as GATE-16 or ATG8L, is a ubiquitin-like protein belonging to the GABARAP family, which plays critical roles in intracellular membrane trafficking, autophagy, and apoptosis. It shares structural homology with other family members, such as GABARAP and LC3. and is involved in autophagosome formation by mediating cargo recognition and vesicle tethering. GABARAPL2 interacts with components of the autophagy machinery, including ATG5-ATG12 conjugates, and facilitates the maturation of autophagosomes by promoting their fusion with lysosomes. Beyond autophagy, it contributes to GABA receptor clustering and modulates neurotransmitter signaling in the brain.
Antibodies targeting GABARAPL2 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate autophagy dynamics, particularly in diseases such as cancer, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s), and metabolic syndromes. Dysregulation of GABARAPL2 has been linked to tumor progression, neuronal degradation, and impaired protein homeostasis. Research utilizing GABARAPL2 antibodies often focuses on elucidating its role in stress responses, cell survival, and interactions with viral pathogens. High-specificity monoclonal or polyclonal antibodies enable precise detection, aiding in biomarker discovery and therapeutic target validation.
×
